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超声辅助提取蒺藜中富含原薯蓣皂苷的提取物的 ANN 建模和 RSM 优化

ANN modeling and RSM optimization of ultrasound-assisted extraction of protodioscin-rich extracts from Tribulus terrestris L.

机构信息

Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje, 16 Rugjer Boskovic Street, 1000 Skopje, North Macedonia.

Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje, 16 Rugjer Boskovic Street, 1000 Skopje, North Macedonia.

出版信息

Ultrason Sonochem. 2024 Dec;111:107141. doi: 10.1016/j.ultsonch.2024.107141. Epub 2024 Nov 7.

DOI:10.1016/j.ultsonch.2024.107141
PMID:39531938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11600060/
Abstract

Tribulus terrestris L. is a herb renowned for its abundance of saponins, flavonoids, and alkaloids, which are utilized in treating various health conditions. Protodioscin functions by enhancing the conversion of testosterone into potent dihydrotestosterone, stimulating an increase in libido, red blood cell production from the bone marrow, and muscle development. Contemporary ultrasound-assisted-extraction (UAE) process employing green extraction solvents was selected to design the required separation system. The experimental plan was developed based on the independent operating variables - extraction time, operating temperature and solvent system composition in order to determine the influence of defined parameters and their interactions on the extraction yield and the presence of protodioscin. The 3D-RSM approach was introduced to determine the optimal values of studied independent variables in the area of maximal extraction yield. UAE process performed at optimal operating conditions generated maximal extraction yield (31 %, w/w) and protodioscin content of 5.9 mg/g dry plant matrix. Experimental data was used to develop an ANN for the defined extraction system using the operating variables values as the input matrix and observed yield as target matrix. Successfully designed and trained ANN generated high correlation (r = 0.9992) between observed data and predictive model' outputs, and MSE value of 0.29107.

摘要

蒺藜是一种以其丰富的三萜皂苷、黄酮类和生物碱而闻名的草本植物，用于治疗各种健康状况。原薯蓣皂苷通过增强睾酮转化为强效二氢睾酮的作用，刺激性欲、骨髓中红细胞生成和肌肉发育的增加。选择当代超声辅助提取 (UAE) 工艺和绿色提取溶剂来设计所需的分离系统。实验方案基于独立操作变量 - 提取时间、操作温度和溶剂系统组成来制定，以确定定义参数及其相互作用对提取率和原薯蓣皂苷存在的影响。引入了 3D-RSM 方法来确定最大提取率区域中研究的独立变量的最佳值。在最佳操作条件下进行的 UAE 工艺产生了最大提取率（31%，w/w）和 5.9mg/g 干植物基质中原薯蓣皂苷的含量。使用作为输入矩阵的操作变量值和观察到的产率作为目标矩阵，将实验数据用于定义提取系统的 ANN。成功设计和训练的 ANN 生成了观察数据和预测模型输出之间的高相关性（r=0.9992），以及 MSE 值为 0.29107。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/eb8aee6b6311/gr13.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/eb8aee6b6311/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/598c107a83f1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/e4c330497e16/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/d32d1bf1d931/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/a2c576ea1f3c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/70ebd3b0f6a5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/594ea57a8078/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/f94d5e00b549/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/88efec3a99b0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/4807fd4db0ea/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/a6909ba05286/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/034d3bbf673e/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/fca27037fc99/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409b/11600060/eb8aee6b6311/gr13.jpg

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