Aragón Felix, Perdigón Gabriela, de Moreno de LeBlanc Alejandra
Felix Aragón, Gabriela Perdigón, Alejandra de Moreno de LeBlanc, Centro de Referencia para Lactobacilos (CERELA-CONICET), T4000ILC San Miguel de Tucumán, Tucumán, Argentina.
World J Clin Oncol. 2014 Aug 10;5(3):455-64. doi: 10.5306/wjco.v5.i3.455.
The population tends to consume foods that in addition to their nutritional values can offer some benefits to their health. There are many epidemiological evidences and research studies in animal models suggesting that diet plays an important role in breast cancer prevention or progression. This review summarized some of the relevant researches about nutrition and cancer during the last years, especially in breast cancer. The analysis of probiotics and fermented products containing lactic acid bacteria in cancer prevention and/or treatment was especially discussed. It was observed that a balance of fatty acids similar to those of traditional Mediterranean diet, the consumption of fruits and vegetables, dietary fiber intake, vitamin supplementation are, along with the intake of probiotic products, the most extensively studied by the negative association to breast cancer risk. The consumption of probiotics and fermented products containing lactic acid bacteria was associated to reduce breast cancer risk in some epidemiological studies. The use of animal models showed the modulation of the host's immune response as one of the important effects associated to the benefices observed with most probiotics. However; future assays in human are very important before the medical community can accept the addition of probiotic or fermented milks containing lactic acid bacteria as supplements for cancer patients.
人们倾向于食用除了具有营养价值之外还能对健康有益的食物。有许多流行病学证据以及动物模型研究表明,饮食在乳腺癌的预防或进展中起着重要作用。这篇综述总结了过去几年中一些关于营养与癌症的相关研究,尤其是乳腺癌方面的研究。特别讨论了益生菌和含乳酸菌的发酵产品在癌症预防和/或治疗中的分析。据观察,与传统地中海饮食相似的脂肪酸平衡、水果和蔬菜的食用、膳食纤维的摄入、维生素补充剂,以及益生菌产品的摄入,是与乳腺癌风险呈负相关研究最为广泛的因素。在一些流行病学研究中,食用益生菌和含乳酸菌的发酵产品与降低乳腺癌风险有关。动物模型研究表明,调节宿主的免疫反应是大多数益生菌所观察到的益处的重要相关效应之一。然而,在医学界能够接受将益生菌或含乳酸菌的发酵牛奶作为癌症患者的补充剂之前,未来的人体试验非常重要。