Wang X, Zhang Z, Chen Q, Li J, Xian J
From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Nasal Diseases, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Clin Radiol. 2014 Nov;69(11):1149-56. doi: 10.1016/j.crad.2014.07.003. Epub 2014 Aug 10.
To evaluate the value of 3 T Periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) DUO diffusion-weighted MRI (DW-MRI) in differentiating sinonasal lymphomas from carcinomas.
PROPELLER DUO DW-MRI was performed in 23 patients with sinonasal lymphomas and 28 patients with carcinomas histologically confirmed at 3 T MRI. Apparent diffusion coefficients (ADCs) were obtained with two different b-values (b = 0 and 700 s/mm(2), b = 0 and 1000 s/mm(2)) and two different regions of interest (ROIs) sampling strategies [whole section (WS), partial section (PS)], respectively. Difference in ADCs between sinonasal lymphomas and carcinomas was evaluated using the independent samples t-test or Mann-Whitney U-test. The utility of ADC thresholds for discriminating between them was evaluated by receiver operating characteristic analysis.
ADCs of sinonasal lymphomas (WS ADCb0,700, 0.838 × 10(-3) mm(2)/s) were significantly (p < 0.001) lower than those of carcinomas (WS ADCb0,700, 1.396 × 10(-3) mm(2)/s). Using a WS ADC b0,700 value of 1.040 × 10(-3) mm(2)/s as the threshold value effectively differentiated sinonasal lymphomas from carcinomas with 100% sensitivity, 82.1% specificity, and 82.1% positive and 100% negative predictive values and 90.2% accuracy (b = 0, 700 s/mm(2)). There was no significant difference in diagnostic ability between different b-values settings (p > 0.05) and different sampling strategies of ROIs (p > 0.05), respectively. Additionally, there was significant differences in the ADCs between diffuse large B-cell lymphomas and natural killer (NK)/T-cell lymphomas (p < 0.05).
PROPELLER DUO DW-MRI can effectively differentiate sinonasal lymphomas from carcinomas.
评估3T周期性旋转重叠平行线增强重建（PROPELLER）双扩散加权磁共振成像（DW-MRI）在鉴别鼻窦淋巴瘤与癌方面的价值。
对23例鼻窦淋巴瘤患者和28例经组织学证实的鼻窦癌患者进行3T磁共振成像的PROPELLER双DW-MRI检查。分别采用两种不同的b值（b = 0和700 s/mm²，b = 0和1000 s/mm²）和两种不同的感兴趣区（ROI）采样策略[全层（WS）、部分层（PS）]获取表观扩散系数（ADC）。采用独立样本t检验或Mann-Whitney U检验评估鼻窦淋巴瘤与癌之间ADC的差异。通过受试者工作特征分析评估ADC阈值对两者的鉴别效用。
鼻窦淋巴瘤的ADC（WS ADCb0,700，0.838×10⁻³ mm²/s）显著低于癌（WS ADCb0,700，1.396×10⁻³ mm²/s）（p < 0.001）。以WS ADC b0,700值1.040×10⁻³ mm²/s为阈值可有效鉴别鼻窦淋巴瘤与癌，敏感性为100%，特异性为82.1%，阳性预测值为82.1%，阴性预测值为100%，准确性为90.2%（b = 0，700 s/mm²）。不同b值设置（p > 0.05）和不同ROI采样策略（p > 0.05）之间的诊断能力无显著差异。此外，弥漫性大B细胞淋巴瘤与自然杀伤（NK）/T细胞淋巴瘤之间的ADC存在显著差异（p < 0.05）。
PROPELLER双DW-MRI可有效鉴别鼻窦淋巴瘤与癌。
