Kasemsuwan L, Clongsuesuek P
Otolaryngology Department, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clin Otolaryngol Allied Sci. 1997 Feb;22(1):44-6. doi: 10.1046/j.1365-2273.1997.00857.x.
The clinical and bacteriological efficacy of topical ciprofloxacin in saline solution and a saline solution without antibiotics, for the treatment of otorrhoea, was assessed. Fifty affected ears which had an acute exacerbation of chronic otitis media with tympanic membrane perforation were included in this study. Only 35 ears completed the study. Both medications were randomly given to patients. Therapeutic efficacy was evaluated on the seventh day of treatment. A favourable clinical response was observed in 89.5% of the ciprofloxacin-treated group and in 43.8% of the saline-treated group, respectively (P < 0.005). Bacteriological eradication was also observed to be higher in the ciprofloxacin-treated group (P < 0.005). From these preliminary results, topical ciprofloxacin appears to be effective in curing the acute phase of chronic otitis media.
评估了局部应用环丙沙星生理盐水溶液和不含抗生素的生理盐水溶液治疗耳漏的临床和细菌学疗效。本研究纳入了50只患有慢性中耳炎急性加重伴鼓膜穿孔的患耳。只有35只耳朵完成了研究。两种药物均随机给予患者。在治疗的第七天评估治疗效果。环丙沙星治疗组和生理盐水治疗组分别有89.5%和43.8%观察到良好的临床反应（P<0.005）。环丙沙星治疗组的细菌学根除率也更高（P<0.005）。从这些初步结果来看，局部应用环丙沙星似乎对治愈慢性中耳炎急性期有效。
