Isodon rosthornii 中的生物活性贝壳杉烷二萜。

Bioactive ent-kaurane diterpenoids from Isodon rosthornii.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2013 Jul 26;76(7):1267-77. doi: 10.1021/np400190n. Epub 2013 Jul 2.

DOI:10.1021/np400190n

PMID:23819871

Abstract

Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.

摘要

异罗索辛 A（1），第一个 20-降恩美汀型二萜，和 15 个新的-ent-卡诺烷类化合物，异罗索辛 B-P（2-16），以及 22 个已知的类似物，从罗索霍恩的地上部分分离出来。通过光谱分析阐明了 1-16 的结构。通过单晶 X 射线衍射确定了 2 的相对构型和 3 的绝对构型。对五种人肿瘤细胞系的细胞毒性评价表明，所测试的几种化合物具有抑制作用。此外，12 种分离物对 LPS 激活的 RAW264.7 巨噬细胞中一氧化氮产生具有抑制活性。