Asano Naofumi, Yoshida Akihiko, Kobayashi Eisuke, Yamaguchi Takehiko, Kawai Akira
Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan; Department of Orthopedic Surgery, Keio University, Tokyo 160-8582, Japan.
Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Hum Pathol. 2014 Nov;45(11):2355-8. doi: 10.1016/j.humpath.2014.06.025. Epub 2014 Jul 17.
Diffuse-type tenosynovial giant cell tumor (D-TGCT) is a relatively rare mesenchymal tumor. It is a locally aggressive but virtually nonmetastasizing neoplasm and thus regarded as benign. Only a few D-TGCTs with benign histology have been reported to metastasize. We report an extremely rare case of benign D-TGCT in which multiple metastases developed 9 years after surgery for the primary tumor. The present case suggests that conventional D-TGCT has the potential to form distant metastases, albeit exceptionally rarely, and that this probable implantation phenomenon can be managed conservatively.
弥漫型腱鞘巨细胞瘤（D-TGCT）是一种相对罕见的间叶组织肿瘤。它是一种局部侵袭性但几乎不发生转移的肿瘤，因此被视为良性肿瘤。仅有少数组织学表现为良性的D-TGCT被报道发生转移。我们报告了一例极为罕见的良性D-TGCT病例，该病例在原发性肿瘤手术后9年出现了多处转移。本病例提示，传统的D-TGCT虽极为罕见但有发生远处转移的可能，且这种可能的种植现象可采用保守治疗。
