太平洋岛屿和领地乙型肝炎的流行情况、预防与管理概述。

Overview of hepatitis B prevalence, prevention, and management in the Pacific Islands and Territories.

作者信息

Howell Jessica, Van Gemert Caroline, Lemoine Maud, Thursz Mark, Hellard Margaret

机构信息

Department of Medicine, Imperial College, London, UK; Department of Hepatology, St. Mary's Hospital, London, UK; The Macfarlane-Burnet Institute, Melbourne, Victoria, Australia; Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.

出版信息

J Gastroenterol Hepatol. 2014 Nov;29(11):1854-66. doi: 10.1111/jgh.12684.

DOI:10.1111/jgh.12684

PMID:25131570

Abstract

There are over 500-750 000 deaths per year because of hepatitis B virus (HBV)-related cirrhosis and liver cancer worldwide and the World Health Organization Western Pacific Region has some of the highest endemic levels of HBV in the world, particularly within China, South East Asia and Pacific Island Countries and Territories (PICT). The PICT have unique ethnic diversity and a very high prevalence of smoking and metabolic syndrome, both important risk factors for liver fibrosis and liver cancer. However, in contrast to many Asian countries, there is little published data on HBV prevalence and related liver disease burden in PICT. In this review, the available published literature and World Health Organization data for HBV prevalence and related liver disease and liver cancer burden in PICT is outlined, and unmet needs for improving HBV prevention and control in the region are highlighted.

摘要

全球每年有超过50万至75万人死于乙型肝炎病毒（HBV）相关的肝硬化和肝癌，世界卫生组织西太平洋区域是世界上HBV流行率最高的地区之一，尤其是在中国、东南亚以及太平洋岛国和领地（PICT）。PICT拥有独特的种族多样性，吸烟和代谢综合征的患病率很高，而这两者都是肝纤维化和肝癌的重要风险因素。然而，与许多亚洲国家不同的是，关于PICT中HBV流行率及相关肝病负担的公开数据很少。在本综述中，概述了PICT中有关HBV流行率以及相关肝病和肝癌负担的现有公开文献和世界卫生组织数据，并强调了该地区在改善HBV预防和控制方面未满足的需求。