Aden Abdi Y, Gustafsson L L
Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.
Eur J Clin Pharmacol. 1989;37(4):371-4. doi: 10.1007/BF00558502.
In a randomized double-blind study, the percentage egg reduction and cure rate after the standard schedule of metrifonate treatment of Schistosoma haematobium (3 doses of 7.5 mg.kg-1 at two-weekly intervals; A) and an abbreviated regimen (3 doses of 5 mg.kg-1 in one day; B) were compared in five villages in Somalia. 300 patients who were excreting 20 or more eggs of S. haematobium in 10 ml urine were recruited. The patients were classified according to their home villages and were then, randomly allocated to treatment A or B. They had similar ages, weights and egg output. Each patient received 3 doses of metrifonate and 2 doses of identical appearing placebo. Group A received metrifonate on the 1st, 4th and 5th dosing occasions and placebo on the 2nd and 3rd times. Group B received metrifonate on the 1st, 2nd and 3rd dosing times and placebo on the 4th and 5th times. Two hundred and one patients were followed up from 1 to 6 months. The remaining 99 (33%) patients either did not complete treatment or were lost during follow up. Egg reduction in the groups 1, 2, 3 and 6 months after treatment were 97, 97, 95 and 93% in Group A and 96, 96, 94 and 92% in Group B (NS). Corresponding cure rates for Group A were 52, 50, 48 and 44%, and in Group B they were 47, 48, 43 and 40% (NS). Seven patients from Group A and 9 from Group B complained of minor side-effects.(ABSTRACT TRUNCATED AT 250 WORDS)
在一项随机双盲研究中，在索马里的五个村庄比较了采用标准疗程的敌百虫治疗埃及血吸虫病（每两周一次，共3剂，每剂7.5 mg·kg⁻¹；A）和简化疗程（一天内3剂，每剂5 mg·kg⁻¹；B）后的虫卵减少百分比和治愈率。招募了300名每10毫升尿液中排出20个或更多埃及血吸虫卵的患者。这些患者根据其家乡进行分类，然后随机分配接受治疗A组或B组。他们的年龄、体重和虫卵排出量相似。每位患者接受3剂敌百虫和2剂外观相同的安慰剂。A组在第1、4和5次给药时接受敌百虫，在第2和3次给药时接受安慰剂。B组在第1、2和3次给药时接受敌百虫，在第4和5次给药时接受安慰剂。201名患者接受了1至6个月的随访。其余99名（33%）患者要么未完成治疗，要么在随访期间失访。治疗后1、2、3和6个月A组的虫卵减少率分别为97%、97%、95%和93%，B组分别为96%、96%、94%和92%（无显著性差异）。A组相应的治愈率分别为52%、50%、48%和44%，B组分别为47%、48%、43%和40%（无显著性差异）。A组有7名患者、B组有9名患者抱怨有轻微副作用。（摘要截选至250词）
