Davis A, Bailey D R
Bull World Health Organ. 1969;41(2):209-24.
This paper describes the effect of oral metrifonate, an organophosphorus cholinesterase inhibitor, on Schistosoma haematobium infections.The methodology of initial studies in hospital patients and 3 field trials in schoolchildren, using spaced doses ranging from 5 mg to 15 mg per kg of body-weight is detailed.The expected fall in plasma cholinesterase was confirmed. No major side-effects were encountered and minor symptoms were associated with high doses only.The optimum dose was 7.5 mg per kg, given once every 14 days or once monthly to a maximum of 3 doses if necessary. About two-thirds of patients were cured after 1 or 2 doses, but some 10% of these relapsed within 6 months of treatment. In 2 trials of this dose, cure rates of 71% and 79% were obtained.The authors conclude that metrifonate is a useful addition to oral schistosomicides for the treatment of S. haematobium infections in children, but suggest that more trials with spaced dose regimes are indicated and that further experimental studies are needed to define its mode of action.
本文描述了有机磷胆碱酯酶抑制剂口服敌百虫对埃及血吸虫感染的影响。详细介绍了在住院患者中开展的初步研究方法以及在学童中进行的3项现场试验，这些试验使用了每千克体重5毫克至15毫克不等的间隔剂量。血浆胆碱酯酶预期下降得到证实。未出现重大副作用，仅高剂量会出现轻微症状。最佳剂量为每千克7.5毫克，每14天给药一次，或每月给药一次，必要时最多给药3次。约三分之二的患者在服用1或2剂后治愈，但其中约10%在治疗后6个月内复发。在该剂量的2项试验中，治愈率分别为71%和79%。作者得出结论，敌百虫是口服血吸虫杀虫剂治疗儿童埃及血吸虫感染的有益补充，但建议开展更多间隔剂量方案的试验，并需要进一步的实验研究来确定其作用方式。
