IEEE Trans Biomed Circuits Syst. 2015 Jun;9(3):387-400. doi: 10.1109/TBCAS.2014.2330859. Epub 2014 Aug 13.
This paper presents the design and testing of an electrode driving application specific integrated circuit (ASIC) intended for epidural spinal cord electrical stimulation in rats. The ASIC can deliver up to 1 mA fully programmable monophasic or biphasic stimulus current pulses, to 13 electrodes selected in any possible configuration. It also supports interleaved stimulation. Communication is achieved via only 3 wires. The current source and the control of the stimulation timing were kept off-chip to reduce the heat dissipation close to the spinal cord. The ASIC was designed in a 0.18- μm high voltage CMOS process. Its output voltage compliance can be up to 25 V. It features a small core area (<;0.36 mm(2)) and consumes a maximum of 114 μW during a full stimulation cycle. The layout of the ASIC was developed to be suitable for integration on the epidural electrode array, and two different versions were fabricated and electrically tested. Results from both versions were almost indistinguishable. The performance of the system was verified for different loads and stimulation parameters. Its suitability to drive a passive epidural 12-electrode array in saline has also been demonstrated.
本文介绍了一种用于大鼠硬膜外脊髓电刺激的电极驱动专用集成电路 (ASIC) 的设计和测试。该 ASIC 可提供高达 1 mA 的完全可编程单相或双相刺激电流脉冲，可对任意可能配置的 13 个电极进行选择。它还支持交错刺激。通过仅 3 根线即可实现通信。电流源和刺激定时的控制被保留在片外，以减少靠近脊髓的热耗散。该 ASIC 采用 0.18-μm 高压 CMOS 工艺设计。其输出电压兼容范围可达 25 V。它具有小的核心面积（<0.36 mm2），在完整的刺激周期内最大消耗 114 μW。ASIC 的布局被开发为适合集成在硬膜外电极阵列上，并制造和测试了两个不同的版本。两个版本的结果几乎没有区别。该系统的性能已针对不同的负载和刺激参数进行了验证。还证明了其适用于在盐水中驱动无源硬膜外 12 电极阵列。
