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用于脊髓硬膜外刺激的多电极阵列的设计与制造。

Design and fabrication of a multi-electrode array for spinal cord epidural stimulation.

作者信息

Chang Chih-Wei, Lo Yi-Kai, Gad Parag, Edgerton Reggie, Liu Wentai

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:6834-7. doi: 10.1109/EMBC.2014.6945198.


DOI:10.1109/EMBC.2014.6945198
PMID:25571566
Abstract

A detailed design, fabrication, characterization and test of a flexible multi-site platinum/polyimide based electrode array for electrical epidural stimulation in spinal cord prosthesis is described in this paper. Carefully designed 8.4 μm-thick structure fabrication flow achieves an electrode surface modification with 3.8 times enhanced effective surface area without extra process needed. Measured impedance and phase of two type of electrodes are 2.35±0.21 KΩ and 2.10±0.11 KΩ, -34.25±8.07° and -27.71±8.27° at 1K Hz, respectively. The fabricated arrays were then in-vitro tested by a multichannel neural stimulation system in physiological saline to validate the capability for electrical stimulation. The measured channel isolation on adjacent electrode is about -34dB. Randles cell model was used to investigate the charging waveforms, the model parameters were then extracted by various methods. The measured charge transfer resistance, double layer capacitance, and solution resistance are 1.9 KΩ, 220 nF and 15 KΩ, respectively. The results show that the fabricated array is applicable for electrical stimulation with well characterized parameters. Combined with a multichannel stimulator, this system provides a full solution for versatile neural stimulation applications.

摘要

本文描述了一种用于脊髓假体电硬膜外刺激的基于柔性多部位铂/聚酰亚胺的电极阵列的详细设计、制造、表征和测试。精心设计的8.4μm厚结构制造流程实现了电极表面改性,有效表面积提高了3.8倍,无需额外工艺。两种类型电极在1kHz时测得的阻抗和相位分别为2.35±0.21KΩ和2.10±0.11KΩ,-34.25±8.07°和-27.71±8.27°。然后,通过多通道神经刺激系统在生理盐水中对制造的阵列进行体外测试,以验证电刺激能力。相邻电极上测得的通道隔离度约为-34dB。使用兰德尔电池模型研究充电波形,然后通过各种方法提取模型参数。测得的电荷转移电阻、双层电容和溶液电阻分别为1.9KΩ、220nF和15KΩ。结果表明,制造的阵列适用于具有良好表征参数的电刺激。结合多通道刺激器,该系统为通用神经刺激应用提供了完整的解决方案。

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