用于彩色和近红外荧光图像引导手术的单相机成像系统。
Single camera imaging system for color and near-infrared fluorescence image guided surgery.
作者信息
Chen Zhenyue, Zhu Nan, Pacheco Shaun, Wang Xia, Liang Rongguang
机构信息
College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA ; Beijing Institute of Technology, Key Laboratory of Photoelectronic Imaging Technology and System of Ministry of Education of China, School of Optoelectronics, Beijing 100081, China.
College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
出版信息
Biomed Opt Express. 2014 Jul 25;5(8):2791-7. doi: 10.1364/BOE.5.002791. eCollection 2014 Aug 1.
Near-infrared (NIR) fluorescence imaging systems have been developed for image guided surgery in recent years. However, current systems are typically bulky and work only when surgical light in the operating room (OR) is off. We propose a single camera imaging system that is capable of capturing NIR fluorescence and color images under normal surgical lighting illumination. Using a new RGB-NIR sensor and synchronized NIR excitation illumination, we have demonstrated that the system can acquire both color information and fluorescence signal with high sensitivity under normal surgical lighting illumination. The experimental results show that ICG sample with concentration of 0.13 μM can be detected when the excitation irradiance is 3.92 mW/cm(2) at an exposure time of 10 ms.
近年来，近红外（NIR）荧光成像系统已被开发用于图像引导手术。然而，目前的系统通常体积庞大，并且仅在手术室（OR）的手术灯关闭时才能工作。我们提出了一种单相机成像系统，该系统能够在正常手术照明条件下捕获近红外荧光和彩色图像。通过使用新型RGB-NIR传感器和同步近红外激发照明，我们已经证明该系统能够在正常手术照明条件下以高灵敏度获取颜色信息和荧光信号。实验结果表明，当激发辐照度为3.92 mW/cm²且曝光时间为10 ms时，可以检测到浓度为0.13 μM的吲哚菁绿（ICG）样本。
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