Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
J Zhejiang Univ Sci B. 2021 Mar 15;22(3):171-189. doi: 10.1631/jzus.B2000388.
The role of point-of-care (POC) diagnostics is important in public health. With the support of smartphones, POC diagnostic technologies can be greatly improved. This opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic functions. As a tool, the smartphone is regarded as part of a compact, portable, and low-cost system for real-time POC, even in areas with few resources. By combining near-infrared (NIR) imaging, measurement, and spectroscopy techniques, pathogens can be detected with high sensitivity. The whole process is rapid, accurate, and low-cost, and will set the future trend for POC diagnostics. In this review, the development of smartphone-based NIR fluorescent imaging technology was described, and the quality and potential of POC applications were discussed.
即时诊断在公共卫生中具有重要作用。即时诊断技术在智能手机的支持下得到了极大的改善。这种机会不仅来自于全球大量且快速传播的手机，还来自于它们改进后的成像/诊断功能。智能手机作为一种工具，被视为实时即时诊断的紧凑型、便携式和低成本系统的一部分，即使在资源匮乏的地区也是如此。通过结合近红外（NIR）成像、测量和光谱技术，可以高灵敏度地检测病原体。整个过程快速、准确且低成本，并将为即时诊断设定未来的趋势。在这篇综述中，描述了基于智能手机的近红外荧光成像技术的发展，并讨论了即时诊断应用的质量和潜力。
