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穆尼面部测试的在线版本:表型与基因关联

An online version of the Mooney Face Test: phenotypic and genetic associations.

作者信息

Verhallen Roeland J, Bosten Jenny M, Goodbourn Patrick T, Bargary Gary, Lawrance-Owen Adam J, Mollon J D

机构信息

Department of Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom.

Department of Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom.

出版信息

Neuropsychologia. 2014 Oct;63:19-25. doi: 10.1016/j.neuropsychologia.2014.08.011. Epub 2014 Aug 17.

DOI:10.1016/j.neuropsychologia.2014.08.011
PMID:25138019
Abstract

The Mooney Face Test is a widely used test of face perception, but was originally designed to be administered by personal interview. We have developed a three-alternative forced-choice version for online testing. We tested 397 healthy adults between the ages of 18 and 42 (M=24 years). There was a wide range of performance (64-100% correct; M=89.6%). We observed a significant sex difference favoring males (.31 standard deviation; p =.004). In addition, independently of sex, higher 2D:4D digit ratios were significantly associated with higher scores (ρ=.14, p=.006). A genome-wide association study (GWAS) for a subset of 370 participants identified an association between Mooney performance and a polymorphism in the RAPGEF5 gene (rs1522280; p=9.68×10(-8)). This association survives a permutation test (p=.031).

摘要

穆尼面部测试是一种广泛使用的面部感知测试,但最初设计为通过个人访谈进行。我们开发了一个用于在线测试的三选一强制选择版本。我们测试了397名年龄在18至42岁之间的健康成年人(平均年龄=24岁)。表现范围很广(正确率为64%-100%;平均正确率=89.6%)。我们观察到显著的性别差异,男性更具优势(标准差为0.31;p=0.004)。此外,独立于性别之外,较高的2D:4D指比与较高的分数显著相关(ρ=0.14,p=0.006)。对370名参与者的一个子集进行的全基因组关联研究(GWAS)确定了穆尼测试表现与RAPGEF5基因中的一个多态性(rs1522280;p=9.68×10^(-8))之间的关联。这种关联在置换检验后仍然显著(p=0.031)。

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