中国阿尔茨海默病患者血清白细胞介素-18、-23和-17水平升高。
Increased serum levels of interleukin-18, -23 and -17 in Chinese patients with Alzheimer's disease.
作者信息
Chen Jin-Mei, Jiang Guo-Xin, Li Qing-Wei, Zhou Zhi-Ming, Cheng Qi
机构信息
Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University,, Shanghai, China.
出版信息
Dement Geriatr Cogn Disord. 2014;38(5-6):321-9. doi: 10.1159/000360606. Epub 2014 Aug 13.
AIMS
To evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with Alzheimer's disease (AD), and explore correlations between the three cytokines and relevant parameters.
METHODS
Serum concentrations of IL-18, IL-23 and IL-17 were measured by ELISA for 53 AD patients and 53 sex- and age-matched healthy controls in a community of elderly individuals in a Shanghai suburb.
RESULTS
Serum concentrations of IL-18, IL-23 and IL-17 were significantly higher in AD patients than controls. The serum level of IL-23 was observed to be significantly higher (p = 0.049) in female AD patients than male AD patients. In addition, a significantly inverse correlation was found between IL-18 and MMSE score (rs = -0.356, p = 0.011) for all AD patients.
CONCLUSION
Elevated IL-18, IL-23 and IL-17 levels are observed in AD patients and differences may exist between males and females. Besides, IL-18 may correlate with the severity of AD.
目的
评估中国阿尔茨海默病（AD）患者血清白细胞介素（IL）-18、IL-23和IL-17水平，并探讨这三种细胞因子与相关参数之间的相关性。
方法
采用酶联免疫吸附测定法（ELISA）检测上海郊区一个老年社区中53例AD患者和53例年龄及性别匹配的健康对照者血清中IL-18、IL-23和IL-17的浓度。
结果
AD患者血清中IL-18、IL-23和IL-17的浓度显著高于对照组。观察发现女性AD患者血清IL-23水平显著高于男性AD患者（p = 0.049）。此外，所有AD患者的IL-18与简易精神状态检查表（MMSE）评分之间存在显著负相关（rs = -0.356，p = 0.011）。
结论
AD患者中观察到IL-18、IL-23和IL-17水平升高，且男女之间可能存在差异。此外，IL-18可能与AD的严重程度相关。
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