Hanson Summer, D'Souza Rena N, Hematti Peiman
1 Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center , Houston, Texas.
Tissue Eng Part A. 2014 Aug;20(15-16):2162-8. doi: 10.1089/ten.tea.2013.0359.
Cell-based treatments are being developed as a novel approach for the treatment of many diseases in an effort to repair injured tissues and regenerate lost tissues. Interest in the potential use of multipotent progenitor or stem cells has grown significantly in recent years, specifically the use of mesenchymal stem cells (MSCs), for tissue engineering in combination with extracellular matrix-based scaffolds. An area that warrants further attention is the local or systemic host responses toward the implanted cell-biomaterial constructs. Such immunological responses could play a major role in determining the clinical efficacy of the therapeutic device or biomaterials used. MSCs, due to their unique immunomodulatory properties, hold great promise in tissue engineering as they not only directly participate in tissue repair and regeneration but also modulate the host foreign body response toward the engineered constructs. The purpose of this review was to summarize the current state of knowledge and applications of MSC-biomaterial constructs as a potential immunoregulatory tool in tissue engineering. Better understanding of the interactions between biomaterials and cells could translate to the development of clinically relevant and novel cell-based therapeutics for tissue reconstruction and regenerative medicine.
基于细胞的治疗方法正在作为一种治疗多种疾病的新方法而被开发，旨在修复受损组织并再生丢失的组织。近年来，对多能祖细胞或干细胞潜在用途的兴趣显著增加，特别是间充质干细胞（MSCs）与基于细胞外基质的支架结合用于组织工程。一个值得进一步关注的领域是局部或全身宿主对植入的细胞 - 生物材料构建体的反应。这种免疫反应可能在决定所使用的治疗装置或生物材料的临床疗效方面发挥主要作用。由于其独特的免疫调节特性，间充质干细胞在组织工程中具有巨大潜力，因为它们不仅直接参与组织修复和再生，还能调节宿主对工程构建体的异物反应。本综述的目的是总结间充质干细胞 - 生物材料构建体作为组织工程中潜在免疫调节工具的当前知识状态和应用。更好地理解生物材料与细胞之间的相互作用可以转化为开发用于组织重建和再生医学的临床相关和新型基于细胞的疗法。
