用亚硝酸处理后的米饭产生的致突变性。
Mutagenicity arising from boiled rice on treatment with nitrous acid.
作者信息
Hayatsu H, Hayatsu T
机构信息
Faculty of Pharmaceutical Sciences, Okayama University.
出版信息
Jpn J Cancer Res. 1989 Nov;80(11):1021-3. doi: 10.1111/j.1349-7006.1989.tb02252.x.
Abstract
When an aqueous homogenate of boiled rice was treated with nitrous acid at pH 3, direct-acting mutagens were formed. The presence of the mutagens was demonstrated by isolating the mutagenic fractions through blue-rayon adsorption, a method used to extract polycyclic compounds, and subsequent high-performance liquid chromatography (HPLC). The mutagens were active in Salmonella typhimurium TA100 and TA98 without metabolic activation. Several different mutagens were formed, as judged from the HPLC profile.
摘要
当将煮熟大米的水匀浆在pH 3条件下用亚硝酸处理时，会形成直接作用的诱变剂。通过蓝光吸附（一种用于提取多环化合物的方法）分离诱变级分，随后进行高效液相色谱法（HPLC），证明了诱变剂的存在。这些诱变剂在鼠伤寒沙门氏菌TA100和TA98中具有活性，无需代谢活化。从HPLC图谱判断，形成了几种不同的诱变剂。
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