Fine D H, Challis B C, Hartman P, Van Ryzin J
IARC Sci Publ. 1982(41):379-96.
A kinetic model for estimating the gastric synthesis of N-nitroso compounds and a method for estimating the risk from exposure to volatile nitrosamines are described. A tentative calculation of the possible risks for human gastric cancer, based on extrapolating from literature data on the induction of tumours in rats, suggests that the endogenous formation of non-volatile N-nitroso compounds is more important than that of volatile nitrosamines.
