埃及草药茶浸剂的抗氧化剂及其对癌细胞的抗增殖和细胞毒性活性。

Egyptian herbal tea infusions' antioxidants and their antiproliferative and cytotoxic activities against cancer cells.

作者信息

Elansary Hosam O, Mahmoud Eman A

机构信息

a Biodiversity Institute of Ontario, University of Guelph , ON N1G 2W1 , Guelph , Canada.

出版信息

Nat Prod Res. 2015;29(5):474-9. doi: 10.1080/14786419.2014.951354. Epub 2014 Aug 21.

DOI:10.1080/14786419.2014.951354

PMID:25141946

Abstract

The antioxidant, antiproliferative and cytotoxic activities against different human cancer cells were investigated in local and recently introduced plants of Mentha sp., Rosmarinus officinalis L. (ROL) and Origanum majorana L. (OML). ROL exhibited the highest antioxidant activities (IC50 8.4 ± 0.2 μg/mL) followed by OML and mint species such as Mentha suaveolens 'apple mint' and Mentha longifolia L. exhibiting moderate antioxidant activities. HPLC analysis of leaf extract revealed that rosmarinic acid is the main component followed by caffeic acid. Herbal leaf extracts varied in their proliferation inhibition and cytotoxicity against HeLa, MCF-7 and Jurkat cancer cells in a dose-dependent matter. The highest antiproliferative inhibition and cytotoxic activity were detected in ROL and OML followed by mint. Local herbs might have a potential role as anticancer natural medicines in addition to their high antioxidant activities due to the presence of different phenolics in their aqueous tea extracts.

摘要

对薄荷属、迷迭香（Rosmarinus officinalis L., ROL）和马郁兰（Origanum majorana L., OML）等本地及近期引进植物的抗氧化、抗增殖及对不同人类癌细胞的细胞毒性活性进行了研究。ROL表现出最高的抗氧化活性（IC50为8.4±0.2μg/mL），其次是OML以及诸如苹果薄荷（Mentha suaveolens）和长叶薄荷（Mentha longifolia L.）等薄荷品种，它们表现出中等抗氧化活性。叶提取物的HPLC分析表明，迷迭香酸是主要成分，其次是咖啡酸。草药叶提取物对HeLa、MCF-7和Jurkat癌细胞的增殖抑制和细胞毒性呈剂量依赖性变化。在ROL和OML中检测到最高的抗增殖抑制和细胞毒性活性，其次是薄荷。由于其水茶提取物中存在不同的酚类物质，本地草药除了具有高抗氧化活性外，可能还具有作为抗癌天然药物的潜在作用。