血管紧张素转换酶I/D多态性与急性呼吸窘迫综合征
Angiotensin-converting enzyme I/D polymorphism and acute respiratory distress syndrome.
作者信息
Deng Xingqi, Zhang Shaokun, Jin Kun, Li Lanyan, Gu Wei, Liu Mei, Zhou Ling
机构信息
Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China
Department of Respiratory Medicine, Second People's Hospital of Weifang, Weifang, Shandong, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):780-6. doi: 10.1177/1470320315576255. Epub 2015 Apr 12.
BACKGROUND
Some studies have assessed the association between angiotensin-converting enzyme (ACE) I/D polymorphism and acute respiratory distress syndrome (ARDS) risk. However, the results have been inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between ACE I/D polymorphism and ARDS risk.
METHODS
All relevant studies were searched using PubMed and EMBASE. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models.
RESULTS
A total of 14 studies with 5218 subjects were included in this meta-analysis. We found that ACE I/D polymorphism significantly associated with an increased ARDS risk (OR=1.57; 95% CI 1.30-1.89; P<0.00001). In the subgroup analysis by race, Caucasians with ACE I/D polymorphism showed increased ARDS risk (OR=1.63; 95% CI 1.32-2.02; P<0.00001). However, Asians with this polymorphism did not show significantly increased ARDS risk (OR=1.31; 95% CI 0.90-1.90; P=0.95). In the subgroup analysis by age group, adults showed increased ARDS risk (OR=1.60; 95% CI 1.32-1.93; P<0.00001), while pediatric patients did not have increased ARDS risk (OR=1.15; 95% CI 0.57-2.30; P=0.70).
CONCLUSIONS
This meta-analysis suggested that ACE I/D polymorphism might contribute to the susceptibility for ARDS.
背景
一些研究评估了血管紧张素转换酶（ACE）I/D多态性与急性呼吸窘迫综合征（ARDS）风险之间的关联。然而，结果尚无定论且相互矛盾。因此，我们进行了一项荟萃分析以研究ACE I/D多态性与ARDS风险之间的关联。
方法
使用PubMed和EMBASE检索所有相关研究。采用随机效应模型或固定效应模型估计比值比（OR）及相应的95%置信区间（CI）。
结果
本荟萃分析共纳入14项研究，涉及5218名受试者。我们发现ACE I/D多态性与ARDS风险增加显著相关（OR=1.57；95%CI 1.30-1.89；P<0.00001）。在按种族进行的亚组分析中，具有ACE I/D多态性的白种人ARDS风险增加（OR=1.63；95%CI 1.32-2.02；P<0.00001）。然而，具有这种多态性的亚洲人ARDS风险并未显著增加（OR=1.31；95%CI 0.90-1.90；P=0.95）。在按年龄组进行的亚组分析中，成年人ARDS风险增加（OR=1.60；95%CI 1.32-1.93；P<0.00001），而儿科患者ARDS风险未增加（OR=1.15；95%CI 0.57-2.30；P=0.70）。
结论
这项荟萃分析表明，ACE I/D多态性可能与ARDS易感性有关。
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