Rasch Sebastian, Algül Hana
II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Clin Exp Gastroenterol. 2014 Aug 11;7:261-72. doi: 10.2147/CEG.S43457. eCollection 2014.
Chronic inflammation has been identified as an important risk factor for the development of malignancy, and knowledge about its molecular and cellular mechanisms is increasing. Several chronic inflammatory diseases of the gastrointestinal tract are important as risk factors for malignancy and have been studied in detail. In this review, we summarize important molecular mechanisms in chronic inflammation and highlight established and potential links between chronic inflammation and gastrointestinal cancer. In addition, we present the role of chronic inflammation in numerous tumors within the gastrointestinal tract as well as the relevant pathways or epidemiologic observations linking the pathogenesis of these tumors to inflammation.
慢性炎症已被确认为恶性肿瘤发生的一个重要危险因素，并且关于其分子和细胞机制的知识正在不断增加。几种胃肠道慢性炎症性疾病作为恶性肿瘤的危险因素很重要，并且已经得到了详细研究。在本综述中，我们总结了慢性炎症中的重要分子机制，并强调了慢性炎症与胃肠道癌症之间已确立的和潜在的联系。此外，我们阐述了慢性炎症在胃肠道内众多肿瘤中的作用，以及将这些肿瘤的发病机制与炎症联系起来的相关途径或流行病学观察结果。
