不止是胆固醇转运蛋白：中枢神经系统功能与神经退行性变中的脂蛋白受体
More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.
作者信息
Lane-Donovan Courtney, Philips Gary T, Herz Joachim
机构信息
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
出版信息
Neuron. 2014 Aug 20;83(4):771-87. doi: 10.1016/j.neuron.2014.08.005.
Abstract
Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.
摘要
低密度脂蛋白（LDL）受体基因家族的成员具有一系列多样的生物学功能，这些功能超越了脂质代谢。脂蛋白受体在发育中的大脑和成年大脑中都有广泛作用，并参与突触发育、货物运输和信号转导。此外，几个家族成员在阿尔茨海默病（AD）发病机制和神经退行性变中起关键作用。本综述总结了我们目前对脂蛋白受体在中枢神经系统功能和AD病理学中所起作用的理解，特别强调了在内吞作用和突触功能障碍中与淀粉样蛋白无关的作用。
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