Reddy Doodipala S, Rogawski Michael A
Texas A&M Health Science Center, College Station, Texas 7784, U.S.A.
University of California, Davis, Sacramento, California 95825, U.S.A.
Epilepsia. 2010;51(Suppl 5):84. doi: 10.1111/j.1528-1167.2010.02870.x.
Neurosteroids such as allopregnanolone are positive allosteric modulators of GABA receptors with powerful antiseizure activity in diverse animal models. Neurosteroids may be endogenous regulators of seizure susceptibility, for example, in catamenial epilepsy. Clinical trials with the synthetic neurosteroid analog ganaxolone in the treatment of refractory partial seizures and infantile spasms have been encouraging. Neurosteroids and analogs such as ganaxolone show promise in the treatment of diverse forms of epilepsy. For an expanded treatment of this topic see 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at www.ncbi.nlm.nih.gov/books).
神经甾体如别孕烯醇酮是γ-氨基丁酸（GABA）受体的正变构调节剂，在多种动物模型中具有强大的抗癫痫活性。神经甾体可能是癫痫易感性的内源性调节因子，例如在经期癫痫中。合成神经甾体类似物加奈索酮治疗难治性部分性癫痫和婴儿痉挛症的临床试验令人鼓舞。神经甾体和诸如加奈索酮之类的类似物在治疗多种形式的癫痫方面显示出前景。有关该主题的扩展论述，请参阅牛津大学出版社出版的第4版（Noebels JL、Avoli M、Rogawski MA、Olsen RW、Delgado-Escueta AV主编）（可在国家医学图书馆书架[NCBI]上查阅，网址为www.ncbi.nlm.nih.gov/books）。
