Bergman Martin J, Castrejón Isabel, Pincus Theodore
Bull Hosp Jt Dis (2013). 2014;72(2):142-7.
A physician estimate of global status (DOCGL) is among the seven core data set measures to assess patients with rheumatoid arthritis (RA) and included in many rheumatic disease indices. In clinical trials designed to reduce in flammation, DOCGL is directed to estimate inflammatory activity. However, patients with inflammatory rheumatic diseases also may be affected by organ damage (e.g., to joints in RA, kidneys in SLE, muscles in polymyositis, and so forth.). Furthermore, fibromyalgia has been reported in 20% to 40% of patients with RA and other inflammatory rheumatic diseases, which may complicate their management. We sought to clarify a global summary of patient status by supplementing DOCGL with three additinal separate (0-10) physician global estimates for inflammation (DOCINF), damage (DOCDAM), and neither inflammation nor damage (DOCNON) (often fibromyalgia, but may be other chronic pain or somatization syndromes). In analyses of new patients with six diagnoses, mean overall DOCGL scores were highest for patients with fibromyalgia, followed by RA, spondyloarthropathy, osteoarthritis, gout, and systemic lupus erythematosus. Among the three subscales, mean DOCINF scores were highest in RA, spondyloar- thropathy, gout, and systemic lupus erythematosus; mean DOCDAM highest in osteoarthritis; and mean DOCNON in fibromyalgia. In patients with RA, mean DOCDAM and DOCNON scores indicated coexistence of clinically impor tant damage or fibromyalgia in some patients. These data indicate face validity of the three physician global estimates on subscales for inflammation, damage, and symptoms due to neither inflammation nor damage. These estimates reflect the expertise of the rheumatologist and may be helpful to interpret rheumatic disease indices.
医生对整体状况的评估(DOCGL)是评估类风湿关节炎(RA)患者的七项核心数据集指标之一,并被纳入许多风湿性疾病指数中。在旨在减轻炎症的临床试验中,DOCGL用于评估炎症活动。然而,炎性风湿性疾病患者也可能受到器官损害(例如,RA中的关节、SLE中的肾脏、多发性肌炎中的肌肉等)的影响。此外,据报道,20%至40%的RA和其他炎性风湿性疾病患者患有纤维肌痛,这可能会使他们的治疗复杂化。我们试图通过补充DOCGL,增加三项单独的(0至10分)医生对炎症(DOCINF)、损害(DOCDAM)以及既无炎症也无损害(DOCNON)(通常为纤维肌痛,但也可能是其他慢性疼痛或躯体化综合征)的整体评估,来明确患者状况的总体概述。在对六种诊断的新患者进行的分析中,纤维肌痛患者的平均总体DOCGL评分最高,其次是RA、脊柱关节炎、骨关节炎、痛风和系统性红斑狼疮。在三个子量表中,RA、脊柱关节炎、痛风和系统性红斑狼疮患者的平均DOCINF评分最高;骨关节炎患者的平均DOCDAM评分最高;纤维肌痛患者的平均DOCNON评分最高。在RA患者中,平均DOCDAM和DOCNON评分表明部分患者存在临床上重要的损害或纤维肌痛。这些数据表明,医生对炎症、损害以及既无炎症也无损害引起的症状的三项整体评估在子量表上具有表面效度。这些评估反映了风湿病学家的专业知识,可能有助于解释风湿性疾病指数。