一种用于眼内压自我监测的植入式微流控装置。
An implantable microfluidic device for self-monitoring of intraocular pressure.
机构信息
1] Department of Bioengineering, Stanford University, Stanford, California, USA. [2] Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.
Department of Bioengineering, Stanford University, Stanford, California, USA.
出版信息
Nat Med. 2014 Sep;20(9):1074-8. doi: 10.1038/nm.3621. Epub 2014 Aug 24.
Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation and is dependent on body posture, so the occasional measurements done by the eye care expert in the clinic can be misleading. Here we show that microfluidic principles can be used to develop an implantable sensor that has a limit of detection of 1 mm Hg, high sensitivity and excellent reproducibility. This device has a simple optical interface that enables IOP to be read with a smartphone camera. This sensor, with its ease of fabrication and simple design, as well as its allowance for IOP home monitoring, offers a promising approach for better care of patients with glaucoma.
青光眼是全球第二大致盲眼病。它是一种多因素疾病，有几个风险因素，其中眼压（IOP）是一个主要的致病因素。IOP 测量用于青光眼诊断和患者监测。IOP 有很大的昼夜波动，并且依赖于身体姿势，因此眼科专家在诊所偶尔进行的测量可能会产生误导。在这里，我们展示了微流控原理可用于开发一种可植入传感器，其检测限为 1 毫米汞柱，具有高灵敏度和出色的重现性。该设备具有简单的光学接口，可使用智能手机摄像头读取 IOP。这种传感器具有易于制造和简单的设计，以及允许在家中监测 IOP 的功能，为更好地治疗青光眼患者提供了一种很有前途的方法。
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