Browne Heidi A, Gair Shannon L, Scharf Jeremiah M, Grice Dorothy E
OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.
Psychiatr Clin North Am. 2014 Sep;37(3):319-35. doi: 10.1016/j.psc.2014.06.002. Epub 2014 Jul 23.
Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.
双胞胎和家系研究支持强迫症（OCD）及相关疾病，如慢性抽动障碍、拔毛癖、皮肤搔抓障碍、躯体变形障碍和囤积障碍，存在显著的遗传因素。最近，基于人群的研究和新的实验室方法证实了强迫症具有很高的遗传性。全基因组关联研究和候选基因关联研究提供了可能参与强迫症病理生物学的特定基因变异信息，尽管很大一部分遗传风险结构仍不清楚。
