强迫症及相关障碍的遗传学
Genetics of obsessive-compulsive disorder and related disorders.
作者信息
Browne Heidi A, Gair Shannon L, Scharf Jeremiah M, Grice Dorothy E
机构信息
OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.
出版信息
Psychiatr Clin North Am. 2014 Sep;37(3):319-35. doi: 10.1016/j.psc.2014.06.002. Epub 2014 Jul 23.
Abstract
Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.
摘要
双胞胎和家系研究支持强迫症（OCD）及相关疾病，如慢性抽动障碍、拔毛癖、皮肤搔抓障碍、躯体变形障碍和囤积障碍，存在显著的遗传因素。最近，基于人群的研究和新的实验室方法证实了强迫症具有很高的遗传性。全基因组关联研究和候选基因关联研究提供了可能参与强迫症病理生物学的特定基因变异信息，尽管很大一部分遗传风险结构仍不清楚。
相似文献
1
Genetics of obsessive-compulsive disorder and related disorders.强迫症及相关障碍的遗传学
Psychiatr Clin North Am. 2014 Sep;37(3):319-35. doi: 10.1016/j.psc.2014.06.002. Epub 2014 Jul 23.
2
The structure of genetic and environmental risk factors for dimensional representations of DSM-5 obsessive-compulsive spectrum disorders.DSM-5 强迫谱系障碍多维表现的遗传和环境风险因素结构。
JAMA Psychiatry. 2014 Feb;71(2):182-9. doi: 10.1001/jamapsychiatry.2013.3524.
3
Genetics of OCD and Related Disorders; Searching for Shared Factors.强迫症及相关障碍的遗传学研究：寻找共同因素
Curr Top Behav Neurosci. 2021;49:1-16. doi: 10.1007/7854_2020_194.
4
Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know.强迫症及相关障碍的基因组学：临床医生需要了解的内容。
Psychiatr Clin North Am. 2023 Mar;46(1):39-51. doi: 10.1016/j.psc.2022.11.003. Epub 2022 Dec 13.
5
Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates.强迫症患者的强迫谱系障碍聚类分析：临床与遗传相关性
Compr Psychiatry. 2005 Jan-Feb;46(1):14-9. doi: 10.1016/j.comppsych.2004.07.020.
6
Genetic studies of obsessive-compulsive disorder.强迫症的遗传学研究。
Ann Clin Psychiatry. 1993 Dec;5(4):241-7. doi: 10.3109/10401239309148823.
7
Tourette's syndrome, trichotillomania, and obsessive-compulsive disorder: how closely are they related?妥瑞氏症候群、拔毛癖、强迫症：它们之间关系有多密切？
Psychiatry Res. 2009 Nov 30;170(1):32-42. doi: 10.1016/j.psychres.2008.06.008. Epub 2009 Oct 3.
8
The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study.强迫症与抽动障碍相关的家族表型：霍普金斯强迫症家族研究
Biol Psychiatry. 2001 Oct 15;50(8):559-65. doi: 10.1016/s0006-3223(01)01074-5.
9
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22.18q22处为抽动秽语综合征/强迫症/慢性抽动障碍的候选基因座。
Am J Med Genet A. 2004 Sep 15;130A(1):37-9. doi: 10.1002/ajmg.a.30066.
10
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.对抽动秽语综合征和强迫症的遗传力进行划分，揭示了遗传结构的差异。
PLoS Genet. 2013 Oct;9(10):e1003864. doi: 10.1371/journal.pgen.1003864. Epub 2013 Oct 24.
引用本文的文献
1
Biological, Psychosocial, and Microbial Determinants of Childhood-Onset Obsessive-Compulsive Disorder: A Narrative Review.儿童期起病的强迫症的生物学、心理社会和微生物学决定因素：一项叙述性综述
Children (Basel). 2025 Aug 13;12(8):1063. doi: 10.3390/children12081063.
2
The Familial Burden: Recognizing Obsessive-Compulsive Disorder Through Proxy Family Members.家族负担：通过代理家庭成员识别强迫症
Cureus. 2025 Feb 10;17(2):e78801. doi: 10.7759/cureus.78801. eCollection 2025 Feb.
3
Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.异质性分析为双相情感障碍的基因同质亚型提供了证据。
PLoS One. 2025 Jan 29;20(1):e0314288. doi: 10.1371/journal.pone.0314288. eCollection 2025.
4
Exploring skin picking disorder: aetiology, treatment, and future directions.探索皮肤搔抓障碍：病因、治疗及未来方向。
Postepy Dermatol Alergol. 2024 Dec;41(6):545-551. doi: 10.5114/ada.2024.142579. Epub 2024 Aug 9.
5
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives.强迫症（OCD）的遗传模式与基因关联：神经精神学见解、基因影响及治疗前景
Curr Gene Ther. 2025;25(3):257-316. doi: 10.2174/0115665232316708240828063527.
6
The genetics of trichotillomania and excoriation disorder: A systematic review.拔毛癖和搔抓障碍的遗传学：系统综述。
Compr Psychiatry. 2024 Aug;133:152506. doi: 10.1016/j.comppsych.2024.152506. Epub 2024 May 31.
7
Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.异质性分析为双相情感障碍的基因同质亚型提供了证据。
ArXiv. 2024 Oct 27:arXiv:2405.00159v2.
8
Negative Impacts of Psychiatric Medications on Oral Health: A Literature Review.精神科药物对口腔健康的负面影响：文献综述
Cureus. 2023 Dec 4;15(12):e49915. doi: 10.7759/cureus.49915. eCollection 2023 Dec.
9
Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families.单卵双生子和多卵双生子强迫症先证者的临床特征。
Psychiatry Res. 2024 Jan;331:115627. doi: 10.1016/j.psychres.2023.115627. Epub 2023 Nov 30.
10
The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis.强迫症的遗传流行病学：系统评价和荟萃分析。
Transl Psychiatry. 2023 Jun 28;13(1):230. doi: 10.1038/s41398-023-02433-2.
本文引用的文献
1
Familial clustering of tic disorders and obsessive-compulsive disorder.抽动障碍和强迫症的家族聚集性。
JAMA Psychiatry. 2015 Apr;72(4):359-66. doi: 10.1001/jamapsychiatry.2014.2656.
2
Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.强迫症和抽动秽语综合征中的拷贝数变异：一项跨疾病研究。
J Am Acad Child Adolesc Psychiatry. 2014 Aug;53(8):910-9. doi: 10.1016/j.jaac.2014.04.022. Epub 2014 Jun 24.
3
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.强迫症的全基因组关联研究：OCGAS研究结果
Mol Psychiatry. 2015 Mar;20(3):337-44. doi: 10.1038/mp.2014.43. Epub 2014 May 13.
4
A family study of trichotillomania and chronic hair pulling.拔毛癖和慢性拔毛发的家族研究。
Am J Med Genet B Neuropsychiatr Genet. 2014 Mar;165B(2):167-74. doi: 10.1002/ajmg.b.32218. Epub 2014 Jan 10.
5
The structure of genetic and environmental risk factors for dimensional representations of DSM-5 obsessive-compulsive spectrum disorders.DSM-5 强迫谱系障碍多维表现的遗传和环境风险因素结构。
JAMA Psychiatry. 2014 Feb;71(2):182-9. doi: 10.1001/jamapsychiatry.2013.3524.
6
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.对抽动秽语综合征和强迫症的遗传力进行划分，揭示了遗传结构的差异。
PLoS Genet. 2013 Oct;9(10):e1003864. doi: 10.1371/journal.pgen.1003864. Epub 2013 Oct 24.
7
Animal models of obsessive-compulsive spectrum disorders.强迫症谱系障碍的动物模型。
CNS Spectr. 2014 Feb;19(1):28-49. doi: 10.1017/S1092852913000564. Epub 2013 Oct 2.
8
Characterization of SLITRK1 variation in obsessive-compulsive disorder.SLITRK1 变异在强迫症中的特征。
PLoS One. 2013 Aug 21;8(8):e70376. doi: 10.1371/journal.pone.0070376. eCollection 2013.
9
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.全基因组关联分析确定了 13 个精神分裂症的新风险位点。
Nat Genet. 2013 Oct;45(10):1150-9. doi: 10.1038/ng.2742. Epub 2013 Aug 25.
10
Family aggregation and risk factors of obsessive-compulsive disorders in a nationwide three-generation study.在一项全国性的三代研究中，强迫症的家族聚集性和危险因素。
Depress Anxiety. 2013 Dec;30(12):1177-84. doi: 10.1002/da.22163. Epub 2013 Aug 6.
Zotero 插件