Napoléon B, Berger F, Espinouse D, Dechavanne M, Mion F, Vignal J, Descos L
Service d'Hépato-Gastroentérologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite.
Gastroenterol Clin Biol. 1989 Nov;13(11):938-41.
A case of gastric plasmacytoma in a 50-year old woman was reported. Immunofluorescent and immunoperoxidase studies were performed. Polyclonal antibodies reactive with immunoglobulin chains and a panel of 14 monoclonal antibodies reactive with B and T cells, and epithelial cells were used. These studies showed that the tumor cells produced IgM Kappa molecules whereas no monotypic immunoglobulin could be detected in the serum and urine. On the other hand the tumor cells had the immunologic phenotype of plasma cells. This helps diagnosis: some lymphomas with plasmocytic differentiation could also produce a monotypic immunoglobulin. Treatment using a combination of surgery, radio and polychimiotherapy was effective, leading to complete remission.
报告了一例50岁女性胃浆细胞瘤病例。进行了免疫荧光和免疫过氧化物酶研究。使用了与免疫球蛋白链反应的多克隆抗体以及一组与B细胞、T细胞和上皮细胞反应的14种单克隆抗体。这些研究表明，肿瘤细胞产生IgM κ分子，而血清和尿液中未检测到单型免疫球蛋白。另一方面，肿瘤细胞具有浆细胞的免疫表型。这有助于诊断：一些具有浆细胞分化的淋巴瘤也可能产生单型免疫球蛋白。采用手术、放疗和多药化疗联合治疗有效，实现了完全缓解。
