一例胃浆细胞瘤：基因分析与免疫固定电泳

A case of gastric plasmacytoma: genetic analysis and immunofixation electrophoresis.

作者信息

Kinoshita Y, Watanabe M, Takahashi H, Itoh T, Kawanami C, Kishi K, Kitajima N, Nakamura T, Inatome T, Inoh T

机构信息

Department of Internal Medicine, Miki City Hospital, School of Allied Medical Sciences, Japan.

出版信息

Am J Gastroenterol. 1991 Mar;86(3):349-53.

PMID:1900144

Abstract

A case of early gastric plasmacytoma in a 66-yr-old woman is reported. The demonstration of monotypic IgM lambda immunoglobulin in plasma cells infiltrating the gastric antrum contributed the histological diagnosis. Genetic analysis of the tumor cells confirmed the presence of a monoclonal neoplastic population of plasma cells in the tumor. Monoclonal immunoglobulin (IgM lambda) was demonstrated in serum, not by conventional immunoelectrophoresis, but by a highly sensitive immunofixation electrophoresis technique. Serum monoclonal immunoglobulin disappeared after subtotal gastrectomy. The value of immunofixation electrophoresis of serum protein and DNA analysis of tumor cells was emphasized for the diagnosis of gastric plasmacytoma.

摘要

报道了一例66岁女性的早期胃浆细胞瘤。在浸润胃窦的浆细胞中发现单型IgMλ免疫球蛋白有助于组织学诊断。肿瘤细胞的基因分析证实肿瘤中存在单克隆浆细胞肿瘤群体。血清中检测到单克隆免疫球蛋白（IgMλ），不是通过传统免疫电泳，而是通过高度敏感的免疫固定电泳技术。胃次全切除术后血清单克隆免疫球蛋白消失。强调了血清蛋白免疫固定电泳和肿瘤细胞DNA分析对胃浆细胞瘤诊断的价值。