Hirofuji E, Tanaka S
Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1989 Nov;63(11):1306-15.
The pharmacological effects of the thyrotropin-releasing hormone (TRH) in relation to biogenic amine metabolism in cerebrospinal fluid were examined in 35 patients with various spinal disorders. Neurologic conditions before and after TRH treatment were evaluated using subjective symptoms and Frankel's classification. Biogenic amine metabolism in cerebrospinal fluid was examined before and after TRH treatment measuring the metabolites by high performance liquid chromatography with electrochemical detection. Significant decreases in metabolites of norepinephrine and dopamine were seen in most cases of spinal disorders. The amount of serotonin metabolite, however, was not changed. In many acute cases, the neurologic condition was improved, and a significant increase in the dopamine metabolite was seen in the improved cases after TRH treatment. In chronic cases, TRH treatment was not as effective as in acute cases. TRH was therefore thought to be an effective agent in the treatment of acute spinal disorders. When an increase in the dopamine metabolite is seen after TRH treatment, neurologic improvement would probably be expected.
在35例患有各种脊柱疾病的患者中，研究了促甲状腺激素释放激素（TRH）与脑脊液中生物胺代谢相关的药理作用。使用主观症状和弗兰克尔分类法评估TRH治疗前后的神经状况。通过高效液相色谱-电化学检测法测量代谢产物，来检测TRH治疗前后脑脊液中的生物胺代谢。在大多数脊柱疾病病例中，去甲肾上腺素和多巴胺的代谢产物显著减少。然而，血清素代谢产物的量没有变化。在许多急性病例中，神经状况得到改善，TRH治疗后病情改善的病例中多巴胺代谢产物显著增加。在慢性病例中，TRH治疗不如急性病例有效。因此，TRH被认为是治疗急性脊柱疾病的有效药物。当TRH治疗后多巴胺代谢产物增加时，可能预期神经状况会改善。
