丙磺舒对腰椎脑脊液中游离及结合型3-甲氧基-4-羟基苯乙二醇（MHPG）的影响。
The effect of probenecid on the free and conjugaed 3-methoxy-4-hydroxyphenylglycol (MHPG) in lumbar cerebrospinal fluid.
作者信息
Karoum F, van Kammen D P, Bunney W E, Gillin J C, Jimerson D C, Post R M, Wyatt R J
出版信息
Psychopharmacol Commun. 1976;2(2):141-8.
Free and conjugated lumbar cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol (MHPG) was measured before and after probenecid treatment in 12 schizophrenic patients by a gas liquid chromatography-mass fragmentographic procedure. Neither the free nor conjugated MHPG was appreciably altered by probenecid. Total MHPG was statistically increased by probenecid but not to the point that the probenecid test would be clinically useful for estimating norepinephrine turnover from probenecid-induced changes in MHPG concentrations.
采用气液色谱 - 质谱碎片分析法，在12例精神分裂症患者中，于丙磺舒治疗前后测定了游离型和结合型腰椎脑脊液3 - 甲氧基 - 4 - 羟基苯乙二醇（MHPG）。丙磺舒对游离型和结合型MHPG均无明显影响。丙磺舒使总MHPG在统计学上有所增加，但未达到丙磺舒试验通过其诱导的MHPG浓度变化来临床评估去甲肾上腺素周转率时有用的程度。
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