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从（L. f.）Ker-Gawl.的根中提取的具有细胞毒性活性的新型甾体皂苷

Novel steroidal saponins with cytotoxic activities from the roots of (L. f.) Ker-Gawl.

作者信息

Wu Yan, Bi Su-Xia, Huang Zhen, Qi Jin, Yu Bo-Yang

机构信息

Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University Nanjing 211198 People's Republic of China

出版信息

RSC Adv. 2018 Jan 11;8(5):2498-2505. doi: 10.1039/c7ra12363a. eCollection 2018 Jan 9.

DOI:10.1039/c7ra12363a
PMID:35541437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077439/
Abstract

Six new steroidal saponins (1-6) and one known steroidal saponin (7) were obtained from the roots of (L. f.) Ker-Gawl. Their structures were determined by the detailed analysis of extensive nuclear magnetic resonance and mass spectroscopic data. The cytotoxic activities of these compounds against MDA-MB-435, HepG2 and A549 cell lines were also investigated.

摘要

从（L. f.）Ker-Gawl.的根中获得了6种新的甾体皂苷（1-6）和1种已知的甾体皂苷（7）。通过对大量核磁共振和质谱数据的详细分析确定了它们的结构。还研究了这些化合物对MDA-MB-435、HepG2和A549细胞系的细胞毒性活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9077439/6a5cbec4cb4c/c7ra12363a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9077439/80134bc7e42c/c7ra12363a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9077439/6a5cbec4cb4c/c7ra12363a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9077439/80134bc7e42c/c7ra12363a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9077439/6a5cbec4cb4c/c7ra12363a-f2.jpg

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2
Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins.不同地理来源麦冬提取物的生物活性成分及药理活性比较。
J Pharm Biomed Anal. 2017 May 10;138:134-141. doi: 10.1016/j.jpba.2017.02.013. Epub 2017 Feb 7.
3
Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway.
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Molecules. 2022 Dec 30;28(1):295. doi: 10.3390/molecules28010295.
4
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RSC Adv. 2019 Feb 26;9(12):6689-6698. doi: 10.1039/c8ra09319a. eCollection 2019 Feb 22.
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Biomed Pharmacother. 2017 Mar;87:118-126. doi: 10.1016/j.biopha.2016.12.093. Epub 2016 Dec 31.
4
Comparison of the chemical consituents and immunomodulatory activity of ophiopogonis radix from two different producing areas.两个不同产地麦冬的化学成分及免疫调节活性比较。
J Pharm Biomed Anal. 2017 Feb 5;134:60-70. doi: 10.1016/j.jpba.2016.11.025. Epub 2016 Nov 13.
5
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MDG-1, a polysaccharide from Ophiopogon japonicus, prevents high fat diet-induced obesity and increases energy expenditure in mice.麦冬多糖 MDG-1 可预防高脂饮食诱导的肥胖，并增加小鼠的能量消耗。
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7
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Phytochemistry. 2014 Nov;107:102-10. doi: 10.1016/j.phytochem.2014.07.021. Epub 2014 Aug 21.
8
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9
Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus.来源于麦冬块根的具有抗炎作用的异黄酮。
Fitoterapia. 2012 Sep;83(6):1042-5. doi: 10.1016/j.fitote.2012.05.011. Epub 2012 May 22.
10
A new eudesmane sesquiterpene glycosides from Liriope muscari.一种来自麦冬的新桉烷型倍半萜糖苷。
J Asian Nat Prod Res. 2012;14(5):491-5. doi: 10.1080/10286020.2012.668533. Epub 2012 Mar 16.