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从(L. f.)Ker-Gawl.的根中提取的具有细胞毒性活性的新型甾体皂苷

Novel steroidal saponins with cytotoxic activities from the roots of (L. f.) Ker-Gawl.

作者信息

Wu Yan, Bi Su-Xia, Huang Zhen, Qi Jin, Yu Bo-Yang

机构信息

Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University Nanjing 211198 People's Republic of China

出版信息

RSC Adv. 2018 Jan 11;8(5):2498-2505. doi: 10.1039/c7ra12363a. eCollection 2018 Jan 9.

Abstract

Six new steroidal saponins (1-6) and one known steroidal saponin (7) were obtained from the roots of (L. f.) Ker-Gawl. Their structures were determined by the detailed analysis of extensive nuclear magnetic resonance and mass spectroscopic data. The cytotoxic activities of these compounds against MDA-MB-435, HepG2 and A549 cell lines were also investigated.

摘要

从(L. f.)Ker-Gawl.的根中获得了6种新的甾体皂苷(1-6)和1种已知的甾体皂苷(7)。通过对大量核磁共振和质谱数据的详细分析确定了它们的结构。还研究了这些化合物对MDA-MB-435、HepG2和A549细胞系的细胞毒性活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9077439/80134bc7e42c/c7ra12363a-f1.jpg

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