Maestrini Viviana, Treibel Thomas A, White Steven K, Fontana Marianna, Moon James C
The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology & Geriatric Sciences, Sapienza University, Rome, Italy.
The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Institute of Cardiovascular Science, University College London, London, WC1E 6BT UK.
Curr Cardiovasc Imaging Rep. 2014;7(9):9287. doi: 10.1007/s12410-014-9287-8.
Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.
心力衰竭（HF）是发病率和死亡率的主要且不断上升的原因。尽管初期取得了成功，但近期治疗进展甚少。需要更好地理解HF病理生理学，并重新关注心肌本身。现在有一种新的成像技术有望带来突破。T1映射是一种用于无创心肌组织特征分析的心血管磁共振（CMR）技术。T1会随疾病发生改变。对比剂注射前（天然）T1会随着纤维化、水肿和浸润等多种过程而变化。如果同时进行对比剂注射后的扫描，则可以测量细胞外容积分数（ECV），这是对间质及其对应物细胞容积的直接测量。这种二分法至关重要——现在可以测量，有望实现更有针对性的治疗，并为疾病生物学带来新的见解。
