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分析临床参数作为突发性聋患者听力恢复的预测因子。

Analysis of clinical parameters as predictors of hearing recovery in patients with sudden sensorineural hearing loss.

机构信息

University Hospital of Split, Department of Otorhinolaryngology-Head and Neck Surgery, Split, Croatia.

University Hospital of Split, Department of Otorhinolaryngology-Head and Neck Surgery, Split, Croatia.

出版信息

Braz J Otorhinolaryngol. 2022 Nov-Dec;88 Suppl 3(Suppl 3):S171-S176. doi: 10.1016/j.bjorl.2022.08.002. Epub 2022 Aug 19.

Abstract

OBJECTIVE

To investigate the impact of certain clinical parameters on likelihood of hearing recovery after SSNHL and to detect potential variables that predict its outcome.

METHODS

A retrospective study was conducted in order to identify the clinical parameters which influence hearing recovery after SSNHL. Medical charts of 87 patients diagnosed with SSNHL and treated in the clinic from January 2015 to December 2019 were retrospectively reviewed. The effects of several parameters on the success of the treatment were statistically evaluated. Such parameters studied were age, gender, the severity of hearing loss, audiometric curve pattern, the time treatment was initiated, and metabolic factors.

RESULTS

Patient categorization according to tonal audiometric curve results statistically differed in terms of recovery (complete, partial, no recovery) (χ = 32.5; p< 0.001). There are 2× more diabetic patients in the group no recovery than in the group partial recovery (OR = 3.1; 95% CI 0.95‒10; p= 0.061), and 5.3× more than in the group complete recovery (OR = 10.4; 95% CI 2.3‒45; p= 0.002) (χ = 11.2; p= 0.004). There is a statistically significant correlation between onset of therapy and recovery on a scale of significance of 93% (χ = 5.3, p= 0.069).

CONCLUSION

In our study tonal audiometry results, diabetes mellitus and onset of therapy were shown to be a statistically significant negative predictive factors for recovery. Results of pure tone audiometry suggest a flat profound curve is statistically associated with the no recovery rates, and a down sloping curve proved to be statistically associated with complete recovery rates.

LEVEL OF EVIDENCE

Level 1.

摘要

目的

探讨某些临床参数对突发性聋后听力恢复的影响,并发现潜在的可预测其结果的变量。

方法

为了确定影响突发性聋后听力恢复的临床参数,进行了一项回顾性研究。回顾性分析了 2015 年 1 月至 2019 年 12 月在我院就诊的 87 例突发性聋患者的病历。对几种参数对治疗效果的影响进行了统计学评估。研究的参数包括年龄、性别、听力损失的严重程度、听力曲线类型、治疗开始时间和代谢因素。

结果

根据纯音测听曲线结果对患者进行分类,在恢复情况(完全、部分、无恢复)方面存在统计学差异(χ=32.5;p<0.001)。无恢复组的糖尿病患者是部分恢复组的 2 倍(OR=3.1;95%CI 0.95-10;p=0.061),是完全恢复组的 5.3 倍(OR=10.4;95%CI 2.3-45;p=0.002)(χ=11.2;p=0.004)。治疗开始时间与恢复程度之间存在统计学显著相关性,显著水平为 93%(χ=5.3,p=0.069)。

结论

在我们的研究中,纯音测听结果、糖尿病和治疗开始时间被证明是恢复的统计学上显著的负预测因素。纯音测听结果表明,平坦的重度曲线与无恢复率呈统计学相关,而下降的曲线与完全恢复率呈统计学相关。

证据水平

1 级。

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本文引用的文献

1
Diabetes mellitus and hearing loss: A review.糖尿病与听力损失:综述
Ageing Res Rev. 2021 Nov;71:101423. doi: 10.1016/j.arr.2021.101423. Epub 2021 Aug 9.
4
Prognostic Factors in Sudden Sensorineural Hearing Loss.突发性感音神经性听力损失的预后因素
Balkan Med J. 2016 Jan;33(1):87-93. doi: 10.5152/balkanmedj.2015.15216. Epub 2016 Jan 1.

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