Bulte Jeff W M
Russell H. Morgan Department of Radiology and Radiological Science and Engineering, Division of MR Research, Cellular Imaging Section, Institute for Cell Engineering The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor Baltimore, MD 21205.
Radiology. 2014 Sep;272(3):615-7. doi: 10.1148/radiol.14141410.
Summary A "hot spot" magnetic resonance (MR) imaging cell tracking technique has been developed that allows direct detection of dysprosium- or thulium-1,4,7,10-tetraazacyclododecane-α,α',α'',α'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA)-labeled protons inside cells. These highly shifted protons may allow specific detection of multiple cell types because it does not rely on acquiring the proton signal from bulk water.
摘要 已开发出一种“热点”磁共振（MR）成像细胞追踪技术，该技术可直接检测细胞内镝或铥-1,4,7,10-四氮杂环十二烷-α,α',α'',α'''-四甲基-1,4,7,10-四乙酸（DOTMA）标记的质子。这些高度位移的质子可能允许对多种细胞类型进行特异性检测，因为它不依赖于从大量水中获取质子信号。
