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在法国通过基于抗原60的IgG血清学检测发现的隐性活动性分枝杆菌感染的发病率

Incidence of inapparent active mycobacterial infections in France detected by an IgG serological test based on antigen 60.

作者信息

Maes R

机构信息

ANDA Biologicals, Strasbourg, France.

出版信息

Med Microbiol Immunol. 1989;178(6):315-21. doi: 10.1007/BF00197450.

DOI:10.1007/BF00197450
PMID:2515425
Abstract

A serological test detecting circulating mycobacterial antibodies of the IgG type applied to various populations. The test detected no positive cases among old age people in a retirement home. Among sexually active women, 3% were positive. This percentage of antigen 60-positive cases was also found among asymptomatic HIV seropositives. The percentage augmented to 5.7% when hospital attendants were analyzed and augmented further to 14% when people known to have had contact with a man suffering from pulmonary tuberculosis were analyzed.

摘要

一种用于检测不同人群中循环IgG型分枝杆菌抗体的血清学检测方法。在一家养老院的老年人中，该检测未发现阳性病例。在性活跃女性中，3%呈阳性。在无症状HIV血清阳性者中也发现了相同比例的抗原60阳性病例。当分析医院护理人员时，该比例增至5.7%，而当分析已知与一名肺结核患者有接触的人群时，该比例进一步增至14%。

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2
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Evaluation of the avidity of IgG anti-mycobacterial antibodies in tuberculous patients serum by an A-60 immunoassay.采用A-60免疫分析法评估结核病患者血清中IgG抗分枝杆菌抗体的亲和力。

本文引用的文献

1
Diagnosis of active tuberculosis by immunological methods. 1. The effect of tuberculin reactivity and previous BCG vaccination on the antibody levels determined by ELISA.通过免疫学方法诊断活动性结核病。1. 结核菌素反应性和既往卡介苗接种对ELISA法测定抗体水平的影响。
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Preparation and properties of antigen 60 from Mycobacterium bovis BCG.卡介苗中抗原60的制备及特性
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Eur J Epidemiol. 1991 Mar;7(2):188-90. doi: 10.1007/BF00237365.
4
Clinical usefulness of serological measurements obtained by antigen 60 in mycobacterial infections: development of a new concept.通过抗原60检测获得的血清学测量在分枝杆菌感染中的临床应用：一种新概念的提出。
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Serological response of tuberculosis patients to antigen 60 of BCG.肺结核患者对卡介苗抗原60的血清学反应。
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6
Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana.
Med Microbiol Immunol. 1992;181(2):71-6. doi: 10.1007/BF00189425.
通过酶联免疫吸附测定（ELISA）未发现克罗恩病血清中存在抗分枝杆菌A60抗原的抗体。
J Med Microbiol. 1988 Apr;25(4):295-8. doi: 10.1099/00222615-25-4-295.
4
Development of an enzyme immunoassay for the serodiagnostic of tuberculosis and mycobacterioses.用于结核病和分枝杆菌病血清诊断的酶免疫测定法的开发。
Med Microbiol Immunol. 1989;178(6):323-35. doi: 10.1007/BF00197451.