Spadari Francesco, Venesia Paolo, Azzi Lorenzo, Veronesi Giovanni, Costantino Dario, Croveri Fabio, Farronato Davide, Tagliabue Angelo, Tettamanti Lucia
Unit of Oral Pathology and Medicine, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Ospedale Maggiore Policlinico IRCCS Ca'Granda Foundation, Milan, Italy.
J Oral Pathol Med. 2015 Mar;44(3):229-33. doi: 10.1111/jop.12240. Epub 2014 Aug 26.
Burning mouth syndrome remains a puzzling condition. One symptom commonly associated with the burning sensation is xerostomia. The current study measured basal and stimulated salivary flow in a group of burning mouth syndrome patients.
Three groups of patients were recruited: 44 burning mouth syndrome patients, 27 oral lichen planus patients and 40 healthy patients. We chose to measure basal salivary flow and stimulated salivary flow in the three groups of patients using the 'spitting' method. Thus, the patients were asked to spit every minute for 5 min. Afterwards, they were asked to repeat the procedure a second time, but a drop of citric acid was positioned on their tongue every minute to stimulate salivary secretion. After 14 days, the same procedure was repeated for 15 min.
Although there was no significant difference between the burning mouth syndrome group and the other two groups regarding the stimulated volumes, an important difference was found in the basal volumes, with the burning mouth syndrome patients showing lower values.
The outcomes of our research demonstrate the presence of very low basal salivary flow in burning mouth syndrome patients compared with the other two groups, but the stimulated salivary flow was equal, if not higher, in the burning mouth syndrome patients. This study contributes new topics for further investigation of a solution to the very mysterious pathology represented by burning mouth syndrome.
灼口综合征仍然是一种令人困惑的病症。与灼痛感觉通常相关的一种症状是口干。本研究测量了一组灼口综合征患者的基础唾液流量和刺激唾液流量。
招募了三组患者：44名灼口综合征患者、27名口腔扁平苔藓患者和40名健康患者。我们选择使用“吐唾液”方法测量三组患者的基础唾液流量和刺激唾液流量。因此，要求患者每分钟吐唾液，持续5分钟。之后，要求他们重复该操作一次，但每分钟在其舌头上滴一滴柠檬酸以刺激唾液分泌。14天后，重复相同操作15分钟。
尽管灼口综合征组与其他两组在刺激唾液量方面没有显著差异，但在基础唾液量方面发现了一个重要差异，灼口综合征患者的基础唾液量较低。
我们的研究结果表明，与其他两组相比，灼口综合征患者的基础唾液流量非常低，但灼口综合征患者的刺激唾液流量即使不更高也相等。这项研究为进一步研究解决由灼口综合征所代表的非常神秘的病理学问题提供了新的课题。
