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唾液腺闪烁扫描定量参数在诊断灼口综合征中的临床应用

Clinical Utility of Quantitative Parameters of Salivary Gland Scintigraphy for Diagnosing Burning Mouth Syndrome.

作者信息

Byeon Hyung Kwon, Jeong Geum Cheol, Kim Beomsoo, Lee Yeongrok, Park Jae Hong, Lee Sang Mi

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Korea.

Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Korea.

出版信息

Diagnostics (Basel). 2022 Sep 18;12(9):2256. doi: 10.3390/diagnostics12092256.

DOI:10.3390/diagnostics12092256
PMID:36140657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9497528/
Abstract

Burning mouth syndrome (BMS) is a chronic disorder characterized by a burning sensation in the oral cavity, often accompanied by xerostomia, with no relevant clinical or laboratory findings. This study aimed to investigate diagnostic values of quantitative parameters of salivary gland scintigraphy for BMS in patients with xerostomia. A total of 164 patients who underwent salivary gland scintigraphy for the workup of xerostomia were retrospectively reviewed. All patients were classified into patient groups with primary BMS, secondary BMS, and non-specific xerostomia. From salivary gland scintigraphy, 22 quantitative parameters were calculated and their diagnostic values were assessed based on the area under the receiver operating characteristic curve (AUC) values. Among salivary gland scintigraphy parameters, uptake speed in the left submandibular gland showed the highest AUC value (0.647) for detecting BMS and pre-stimulatory oral activity showed the highest AUC value (0.710) for detecting primary BMS. A salivary gland scintigraphy scoring system based on these two parameters further enhanced the diagnostic ability, demonstrating AUC values of 0.731 for BMS and 0.782 for primary BMS. These results suggest a potential diagnostic value of the quantitative parameters of salivary gland scintigraphy for detecting BMS in patients with xerostomia.

摘要

灼口综合征（BMS）是一种慢性疾病，其特征为口腔内有烧灼感，常伴有口干，且无相关临床或实验室检查结果。本研究旨在探讨唾液腺闪烁扫描定量参数对口干患者BMS的诊断价值。对164例因口干接受唾液腺闪烁扫描检查的患者进行了回顾性分析。所有患者被分为原发性BMS组、继发性BMS组和非特异性口干组。通过唾液腺闪烁扫描计算了22个定量参数，并根据受试者工作特征曲线（AUC）下面积值评估了它们的诊断价值。在唾液腺闪烁扫描参数中，左下颌下腺的摄取速度在检测BMS时显示出最高的AUC值（0.647），刺激前口腔活性在检测原发性BMS时显示出最高AUC值（0.710）。基于这两个参数的唾液腺闪烁扫描评分系统进一步提高了诊断能力，BMS的AUC值为0.731，原发性BMS的AUC值为0.782。这些结果表明，唾液腺闪烁扫描定量参数对检测口干患者的BMS具有潜在诊断价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/5b5f25f84b08/diagnostics-12-02256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/ca300b7c3f9c/diagnostics-12-02256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/e82bdfcfc695/diagnostics-12-02256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/5b5f25f84b08/diagnostics-12-02256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/ca300b7c3f9c/diagnostics-12-02256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/e82bdfcfc695/diagnostics-12-02256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/9497528/5b5f25f84b08/diagnostics-12-02256-g003.jpg

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本文引用的文献

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Salivary characteristics in burning mouth syndrome: a systematic review.灼口综合征的唾液特征：系统评价。
Minerva Dent Oral Sci. 2022 Aug;71(4):233-241. doi: 10.23736/S2724-6329.22.04647-2.
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Burning Mouth Syndrome Etiology: A Narrative Review.灼口综合征病因：叙述性综述。
J Gastrointestin Liver Dis. 2022 Jun 12;31(2):223-228. doi: 10.15403/jgld-4245.
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Is Burning Mouth Syndrome a Neuropathic Pain Disorder? A Systematic Review.灼口综合征是一种神经病理性疼痛障碍吗？系统评价。
J Oral Facial Pain Headache. 2021;35(3):218-229. doi: 10.11607/ofph.2861.
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Recent Advances in Salivary Scintigraphic Evaluation of Salivary Gland Function.唾液腺功能唾液闪烁显像评估的最新进展
Diagnostics (Basel). 2021 Jun 28;11(7):1173. doi: 10.3390/diagnostics11071173.
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Salivary characteristics may be associated with burning mouth syndrome?唾液特征可能与灼口综合征有关？
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Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome.基于蛋白质组学鉴定灼口综合征患者唾液变化
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