Tettamanti L, Gaudio R M, Cura F, Mucchi D, Illuzzi N, Tagliabue A
Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Oral Implantol (Rome). 2017 Apr 10;10(1):28-36. doi: 10.11138/orl/2017.10.1.028. eCollection 2017 Jan-Mar.
The aim of the present study was to evaluate the prevalence of some periodontal pathogens in Italian adults with chronic periodontitis.
The sample consisted of 2992 patients with a clinical diagnosis of chronic periodontitis, based on the criteria of the American Academy of Periodontology, sampled in the period 2013-2016: 2108 patients were from Northern, 690 from Central and 194 from Southern Italy. and were investigated in all patients of the present study, while and only in 2514 (84%) patients. Subgingival plaque samples of the four sites of greatest probing depth in each patient were used to obtain subgingival microbiota and then processed by quantitative polymerase chain reaction.
Periodontal pathogens had the following presence respect to all amount of patients: 16.1%, 73.4%, 93.8%, 65.5%, 66.4%, and Tannerella forsythia 72.7%. There are no significant statistical differences among geographic areas both for the total bacterial and the single species except for and which prevalence was significantly higher in Southern Italy (P value <.05). The other investigated species were equally distributed among different regions. was the rarer species detected in this study, while was the commonest. No differences among areas where observed as regard of the mean bacterial load except for F. Nucleatum whose prevalence in Northern Italy was lower then both in Central and Southern Italy (P value <.05).
The results of our study didn't show different geographic distribution of periodontal pathogens among Italian population of the three areas investigated. The homogeneity of the results could be related to genetic and environmental factors.
本研究旨在评估意大利慢性牙周炎成年患者中某些牙周病原体的患病率。
样本包括2992例根据美国牙周病学会标准临床诊断为慢性牙周炎的患者，于2013年至2016年期间采样：2108例患者来自意大利北部，690例来自中部，194例来自南部。本研究所有患者均检测了[具体菌种1]和[具体菌种2]，而[具体菌种3]和[具体菌种4]仅在2514例（84%）患者中检测。采集每位患者探测深度最大的四个部位的龈下菌斑样本，以获取龈下微生物群，然后通过定量聚合酶链反应进行处理。
就所有患者数量而言，牙周病原体的存在情况如下：[具体菌种1]为16.1%，[具体菌种2]为73.4%，[具体菌种3]为93.8%，[具体菌种4]为65.5%，[具体菌种5]为66.4%，福赛坦纳菌为72.7%。除了[具体菌种3]和[具体菌种4]在意大利南部的患病率显著更高（P值<.05）外，地理区域之间在总细菌和单一菌种方面均无显著统计学差异。其他检测的菌种在不同区域分布均匀。[具体菌种1]是本研究中检测到的最罕见菌种，而[具体菌种3]是最常见的。除了具核梭杆菌在意大利北部的患病率低于中部和南部（P值<.05）外，各区域在平均细菌载量方面未观察到差异。
我们的研究结果未显示在所调查的意大利三个地区人群中牙周病原体存在不同的地理分布。结果的同质性可能与遗传和环境因素有关。
