Jakicic John M, Rickman Amy D, Lang Wei, Davis Kelliann K, Gibbs Bethany Barone, Neiberg Rebecca, Marcus Marsha D
1Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, Pittsburgh, PA; 2Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University, Winston-Salem, NC; and 3Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Med Sci Sports Exerc. 2015 May;47(5):1061-9. doi: 10.1249/MSS.0000000000000482.
This study aims to examine whether enhancing standard behavioral weight loss interventions (standard behavioral weight loss program (SBWP)) with additional strategies at the initiation of intervention (ADOPT) or providing the additional strategies at predetermined times over the intervention period (MAINTAIN) enhances 18-month weight loss.
This was a clinical trial of participants (N = 195; mean ± SEM: age, 43.2 ± 8.6 yr; body mass index, 33.0 ± 3.4 kg·m) randomized to SBWP, ADOPT, or MAINTAIN. All participants were prescribed an energy-restricted diet and physical activity, with group intervention sessions delivered over 18 months. ADOPT participants received additional phone contact (months 1-3), supervised exercise (months 1-6), and behavior campaigns (months 4-9). MAINTAIN participants received additional phone contact (months 4-6), supervised exercise (months 7-12), and behavior campaigns (months 13-18).
There was a significant group-time interaction for weight loss (P = 0.0032). SBWP participants lost 9.3 ± 0.9, 7.8 ± 1.1, and 5.9 ± 1.2 kg at 6, 12, and 18 months, respectively. ADOPT participants lost 8.9 ± 0.9, 7.6 ± 1.2, and 5.8 ± 1.2 kg, whereas MAINTAIN participants lost 9.7 ± 0.9, 11.0 ± 1.2, and 9.0 ± 1.2 kg at 6, 12, and 18 months, respectively. The group-time interactions for SBWP versus MAINTAIN (P = 0.0033) and for ADOPT versus MAINTAIN (P = 0.0075) were significant. There was a significant group-time interaction for change in fitness (P = 0.0060). The group-time interaction for MAINTAIN versus ADOPT (P = 0.0018) was significant, with a trend for MAINTAIN versus SBWP (P = 0.0525).
MAINTAIN improves 18-month weight loss compared with SBWP and ADOPT, with statistical trends indicating that MAINTAIN results in greater improvements in fitness. These results suggest that time-based strategies emphasizing physical activity confer greater benefits when delivered later and over the full course of intervention. This provides valuable information for the implementation of time-based strategies for improving long-term weight loss and fitness in overweight and obese adults.
本研究旨在探讨在干预开始时采用额外策略强化标准行为减肥干预措施(标准行为减肥计划(SBWP))(ADOPT组),或在干预期内的预定时间提供额外策略(MAINTAIN组)是否能增强18个月时的体重减轻效果。
这是一项针对参与者的临床试验(N = 195;平均值±标准误:年龄,43.2±8.6岁;体重指数,33.0±3.4kg·m²),随机分为SBWP组、ADOPT组或MAINTAIN组。所有参与者都被规定了能量限制饮食和体育活动,并进行为期18个月的小组干预课程。ADOPT组参与者在第1 - 3个月接受额外电话联系,第1 - 6个月接受监督锻炼,第4 - 9个月开展行为活动。MAINTAIN组参与者在第4 - 6个月接受额外电话联系,第7 - 12个月接受监督锻炼,第13 - 18个月开展行为活动。
体重减轻存在显著的组 - 时间交互作用(P = 0.0032)。SBWP组参与者在6个月、12个月和18个月时分别减重9.3±0.9kg、7.8±1.1kg和5.9±1.2kg。ADOPT组参与者在6个月、12个月和18个月时分别减重8.9±0.9kg、7.6±1.2kg和5.8±1.2kg,而MAINTAIN组参与者在6个月、12个月和18个月时分别减重9.7±0.9kg、11.0±1.2kg和9.0±1.2kg。SBWP组与MAINTAIN组(P = 0.0033)以及ADOPT组与MAINTAIN组(P = 0.0075)的组 - 时间交互作用显著。身体适应性变化存在显著的组 - 时间交互作用(P = 0.0060)。MAINTAIN组与ADOPT组的组 - 时间交互作用显著(P = 0.0018),MAINTAIN组与SBWP组有此趋势(P = 0.0525)。
与SBWP组和ADOPT组相比,MAINTAIN组改善了18个月时的体重减轻情况,统计趋势表明MAINTAIN组在身体适应性方面有更大改善。这些结果表明,强调体育活动的基于时间的策略在干预后期及整个干预过程中实施时能带来更大益处。这为实施基于时间的策略以改善超重和肥胖成年人的长期体重减轻和身体适应性提供了有价值的信息。