山谷热：一种古老疾病出现新传播地：在华盛顿州土壤中发现与近期人类感染相关的粗球孢子菌。
Valley fever: finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection.
作者信息
Litvintseva Anastasia P, Marsden-Haug Nicola, Hurst Steven, Hill Heather, Gade Lalitha, Driebe Elizabeth M, Ralston Cindy, Roe Chandler, Barker Bridget M, Goldoft Marcia, Keim Paul, Wohrle Ron, Thompson George R, Engelthaler David M, Brandt Mary E, Chiller Tom
机构信息
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Washington State Department of Health, Shoreline and Tumwater.
出版信息
Clin Infect Dis. 2015 Jan 1;60(1):e1-3. doi: 10.1093/cid/ciu681. Epub 2014 Aug 27.
Abstract
We used real-time polymerase chain reaction and culture to demonstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washington State linked to recent human infections and located outside the endemic range. Whole-genome sequencing confirmed genetic identity between isolates from soil and one of the case-patients.
摘要
我们采用实时聚合酶链反应和培养方法，以证明在华盛顿州与近期人类感染相关且位于地方病流行范围之外的土壤中，存在球孢子菌（一种引起山谷热的病原体）的持续定植。全基因组测序证实了土壤分离株与其中一名病例患者的分离株之间的基因一致性。
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