羊膜液源性干细胞移植治疗实验性缺血性脑卒中的疗效。
Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke.
机构信息
Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine Tampa, FL, USA.
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing, China.
出版信息
Front Cell Neurosci. 2014 Aug 13;8:227. doi: 10.3389/fncel.2014.00227. eCollection 2014.
Accumulating preclinical evidence suggests the use of amnion as a source of stem cells for investigations of basic science concepts related to developmental cell biology, but also for stem cells' therapeutic applications in treating human disorders. We previously reported isolation of viable rat amniotic fluid-derived stem (AFS) cells. Subsequently, we recently reported the therapeutic benefits of intravenous transplantation of AFS cells in a rodent model of ischemic stroke. Parallel lines of investigations have provided safety and efficacy of stem cell therapy for treating stroke and other neurological disorders. This review article highlights the need for investigations of mechanisms underlying AFS cells' therapeutic benefits and discusses lab-to-clinic translational gating items in an effort to optimize the clinical application of the cell transplantation for stroke.
越来越多的临床前证据表明，使用羊膜作为干细胞的来源，可用于研究与发育细胞生物学相关的基础科学概念，也可用于干细胞治疗人类疾病的应用。我们之前曾报道过从大鼠羊水中分离出有活力的羊膜衍生干细胞（AFS 细胞）。随后，我们最近报道了静脉注射 AFS 细胞在缺血性中风啮齿动物模型中的治疗益处。平行的研究线为治疗中风和其他神经疾病的干细胞治疗提供了安全性和有效性。本文综述强调了研究 AFS 细胞治疗益处的潜在机制的必要性，并讨论了实验室到临床的转化门控项目，以优化细胞移植治疗中风的临床应用。
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