Smith I F, Taiwo O, Golden M H
Department of Community Health and Nutrition, University of Ife, Nigeria.
Eur J Clin Nutr. 1989 Nov;43(11):763-8.
Thirty-eight children admitted to the paediatric ward of Obafemi Awolowo University Teaching Hospital, Ile-Ife, were treated using a local therapeutic regimen for protein-energy malnutrition (PEM). Serum transferrin concentration was measured at weekly intervals to determine the response to and nutritional adequacy of the dietary component of this therapeutic regimen. At discharge, weight for height measurements in the children showed a significant (P less than 0.001) increase in growth although the expected weight for height was not attained. Serum transferrin concentration rose significantly from a mean basal level of 132.1 +/- 17.2 mg/dl to 222.0 +/- 24.6 mg/dl at the end of the first week of hospitalization and at discharge was 403.2 +/- 27.8 mg/dl. Although not statistically significant, mortality was highest amongst children for whom iron supplementation started early on admission. Earlier studies on the aetiology and treatment of anaemia in PEM have argued in favour of routine treatment with iron to prevent the development of anaemia during the recovery phase, but data from this study suggest that iron therapy should not be instituted during the first week of treatment.
在伊费的奥巴费米·阿沃洛沃大学教学医院儿科病房收治的38名儿童，采用了一种治疗蛋白质-能量营养不良（PEM）的当地治疗方案进行治疗。每周测量血清转铁蛋白浓度，以确定对该治疗方案饮食成分的反应及营养充足性。出院时，儿童的身高别体重测量显示生长有显著增加（P小于0.001），尽管未达到预期的身高别体重。血清转铁蛋白浓度从平均基础水平132.1±17.2mg/dl在住院第一周结束时显著升至222.0±24.6mg/dl，出院时为403.2±27.8mg/dl。尽管无统计学意义，但入院时早期开始补充铁剂的儿童死亡率最高。早期关于PEM贫血病因及治疗的研究主张常规用铁剂治疗以预防恢复期贫血的发生，但本研究数据表明治疗第一周不应开始铁剂治疗。
