Mirmohammadi Seyed Jalil, Mehrparvar Amir Houshang, Safaei Sara, Nodoushan Mojahede Salmani, Jahromi Mona Torab
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Occup Med Environ Health. 2014 Oct;27(5):707-15. doi: 10.2478/s13382-014-0306-4. Epub 2014 Aug 29.
For the purpose of evaluation of exhaled NO as an index of airway inflammation, we assessed changes in fractional exhaled NO (FeNO) across a work shift and its relationship with respiratory complaints.
Chronic and work-aggravated respiratory complaints were assessed using a questionnaire in 89 male textile workers. FeNO and spirometry were performed before and after a work shift and all the changes were registered.
A significant increase in FeNO after a work shift was observed. Post-shift FeNO was significantly higher among the subjects with chronic respiratory complaints. There was an obvious decrease in FVC, and FEV1 after a work shift; however, we couldn't find a significant relationship between changes in respiratory parameters and concentration of inhalable dusts.
FeNO increase after a work shift along with pulmonary function decrement and higher post-shift FeNO among subjects with respiratory complaints makes across-shift FeNO a non-invasive test for assessment of airway hyper-responsiveness in textile workers.
为了评估呼出一氧化氮作为气道炎症指标的情况，我们评估了整个工作班次中呼出气一氧化氮分数（FeNO）的变化及其与呼吸道症状的关系。
使用问卷对89名男性纺织工人的慢性和工作加重性呼吸道症状进行评估。在工作班次前后进行FeNO和肺功能测定，并记录所有变化。
观察到工作班次后FeNO显著增加。慢性呼吸道症状患者的班后FeNO显著更高。工作班次后用力肺活量（FVC）和第一秒用力呼气容积（FEV1）明显下降；然而，我们未发现呼吸参数变化与可吸入粉尘浓度之间存在显著关系。
工作班次后FeNO增加，同时伴有肺功能下降，且呼吸道症状患者的班后FeNO更高，这使得跨班次FeNO成为评估纺织工人气道高反应性的一种非侵入性检测方法。
