Bei Chun-Hua, Bai Hua, Yu Hong-Ping, Yang Yan, Liang Qing-Qing, Deng Ying-Ying, Tan Sheng-Kui, Qiu Xiao-Qiang
Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, China E-mail :
Asian Pac J Cancer Prev. 2014;15(16):6961-7. doi: 10.7314/apjcp.2014.15.16.6961.
Cytokine gene single nucleotide polymorphisms (SNPs) are involved in the genesis and progression of hepatocellular carcinoma (HCC). We hypothesized that combined effects of cytokine gene SNPs and SNP-SNP interactions are associated with HCC risk. Six SNPs in cytokine genes (IL-2, IFN-γ, IL-1β, IL-6, and IL-10) were genotyped in a study of 720 Chinese HCC cases and 784 cancer-free controls. Although none of these SNPs individually had a significant effect on the risk of HCC, we found that the combined effects of these six SNPs may contribute to HCC risk (OR=1.821, 95% CI=1.078-3.075). This risk was pronounced among smokers, drinkers, and hepatitis B virus carriers. A SNP-SNP interaction between IL-2-330 and IFN-γ-1615 was associated with an increased HCC risk (OR=1.078, 95% CI=1.022-1.136). In conclusion, combined effects of SNPs and SNP-SNP interactions in cytokine genes may contribute to HCC risk.
细胞因子基因单核苷酸多态性（SNPs）与肝细胞癌（HCC）的发生和发展有关。我们假设细胞因子基因SNPs的联合效应以及SNP-SNP相互作用与HCC风险相关。在一项对720例中国HCC病例和784例无癌对照的研究中，对细胞因子基因（IL-2、IFN-γ、IL-1β、IL-6和IL-10）中的6个SNPs进行了基因分型。尽管这些SNPs单独对HCC风险均无显著影响，但我们发现这6个SNPs的联合效应可能会增加HCC风险（OR=1.821，95%CI=1.078-3.075）。这种风险在吸烟者、饮酒者和乙型肝炎病毒携带者中更为明显。IL-2-330和IFN-γ-1615之间的SNP-SNP相互作用与HCC风险增加相关（OR=1.078，95%CI=1.022-1.136）。总之，细胞因子基因中SNPs的联合效应以及SNP-SNP相互作用可能会增加HCC风险。
