Tseng W-L, Bones B L, Kayser R R, Olsavsky A K, Fromm S J, Pine D S, Leibenluft E, Brotman M A
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Georgetown University School of Medicine, Washington, DC, USA.
Eur Psychiatry. 2015 Jan;30(1):94-8. doi: 10.1016/j.eurpsy.2014.05.004. Epub 2014 Aug 27.
Face memory deficits may be a bipolar disorder (BD) endophenotype. BD (n=27) and unaffected youth at risk (n=13) exhibited middle frontal gyrus hypoactivation during successful vs. unsuccessful encoding. Parahippocampal gyrus dysfunction was found in BD and at-risk youth (vs. low-risk, n=37). Middle occipital gyrus hypoactivation was only present in BD.
面部记忆缺陷可能是双相情感障碍(BD)的一种内表型。双相情感障碍患者(n = 27)和有患病风险的未患病青少年(n = 13)在成功编码与未成功编码过程中表现出额中回激活不足。在双相情感障碍患者和有患病风险的青少年中发现了海马旁回功能障碍(与低风险组相比,n = 37)。枕中回激活不足仅出现在双相情感障碍患者中。