Bano Farhat, Ahmed Afrinah, Parveen Tahira, Haider Saida
Department of Biochemistry, Jinnah Medical and Dental Collage, Karachi, Pakistan.
Karachi Medical and Dental Collage, Karachi, Pakistan.
Pak J Pharm Sci. 2014 Sep;27(5 Spec no):1547-52.
Use of the herbal drugs increasing all over the world due to its minimum side effect. Nigella sativa black seeds used in folk medicine for the promotion of good health and for the treatment of many diseases .The present study is designed to investigate the neurochemical and behavioral effect of aqueous extract of Nigella sativa L. seeds in rats. Neurochemical studies were performed for DA and DOPAC levels in whole rats' brain. Locomotive behavior was observed in novel environment and familiar environment. Elevated plus maze and light dark behavioral modules were used to monitor anxiety in rats. The oral administration of AENS for six weeks increased time spent in open arm of elevated plus maze and light compartment in light dark box. Increased locomotors activity in novel environment (open field) was noticed suggesting that increased in DA level may be related to increased locomotive activity in rats.
由于草药副作用极小，其在全球的使用正在增加。黑种草籽在民间医学中用于促进健康和治疗多种疾病。本研究旨在调查黑种草籽水提取物对大鼠的神经化学和行为影响。对大鼠全脑的多巴胺（DA）和二羟基苯乙酸（DOPAC）水平进行了神经化学研究。在新环境和熟悉环境中观察运动行为。使用高架十字迷宫和明暗行为模块来监测大鼠的焦虑情况。连续六周口服黑种草籽水提取物可增加大鼠在高架十字迷宫开放臂和明暗箱亮区的停留时间。在新环境（旷场）中观察到运动活性增加，这表明多巴胺水平的升高可能与大鼠运动活性的增加有关。
