Niemann M, Alkadhi H, Gotschy A, Kozerke S, Manka R
Institut für Biomedizinische Technik, Universität und ETH Zürich, Gloriastr. 35, CH-8092, Zürich, Schweiz,
Herz. 2015 May;40 Suppl 3:282-90. doi: 10.1007/s00059-014-4146-6. Epub 2014 Sep 3.
Since the discovery of the obese (ob) gene product leptin, fat has been considered an endocrine organ. Especially epicardial fat has gained increasing attention in recent years. The epicardial fat plays a major role in fat metabolism; however, harmful properties have also been reported. Echocardiography, computed tomography and cardiac magnetic resonance imaging are the non-invasive tools used to measure epicardial fat volume. This review briefly introduces the basic physiological and pathophysiological considerations concerning epicardial fat. The main issue of this review is the presentation of non-invasive measurement techniques of epicardial fat using various imaging modalities and a literature overview of associations between epicardial fat and common cardiovascular diseases.
自肥胖(ob)基因产物瘦素被发现以来,脂肪一直被视为一个内分泌器官。近年来,尤其是心外膜脂肪越来越受到关注。心外膜脂肪在脂肪代谢中起主要作用;然而,也有报道称其具有有害特性。超声心动图、计算机断层扫描和心脏磁共振成像是非侵入性工具,用于测量心外膜脂肪体积。本综述简要介绍了有关心外膜脂肪的基本生理和病理生理方面的考虑因素。本综述的主要内容是介绍使用各种成像方式对心外膜脂肪进行非侵入性测量的技术,以及心外膜脂肪与常见心血管疾病之间关联的文献综述。