用于磁共振成像的具有高效肾脏清除率的钆包封碳点
Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging.
作者信息
Chen Hongmin, Wang Geoffrey D, Tang Wei, Todd Trever, Zhen Zipeng, Tsang Chu, Hekmatyar Khan, Cowger Taku, Hubbard Richard, Zhang Weizhong, Stickney John, Shen Baozhong, Xie Jin
机构信息
Department of Chemistry, The University of Georgia, Athens, Georgia 30602, USA; Department of Radiology and Molecular Imaging Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P. R. China.
Department of Chemistry, The University of Georgia, Athens, Georgia 30602, USA.
出版信息
Adv Mater. 2014 Oct 22;26(39):6761-6766. doi: 10.1002/adma.201402964. Epub 2014 Sep 1.
Abstract
Nanoprobes for MRI and optical imaging are demonstrated. Gd@C-dots possess strong fluorescence and can effectively enhance signals on T1 -weighted MR images. The nanoprobes have low toxicity, and, despite a relatively large size, can be efficiently excreted by renal clearance from the host after systemic injection.
摘要
展示了用于磁共振成像（MRI）和光学成像的纳米探针。钆@碳点具有强烈的荧光，并且可以有效地增强T1加权磁共振图像上的信号。这些纳米探针具有低毒性，并且尽管尺寸相对较大，但在全身注射后可以通过肾脏清除从宿主体内有效排出。
相似文献
1
Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging.
Adv Mater. 2014 Oct 22;26(39):6761-6766. doi: 10.1002/adma.201402964. Epub 2014 Sep 1.
2
Affibody-Modified Gd@C-Dots with Efficient Renal Clearance for Enhanced MRI of EGFR Expression in Non-Small-Cell Lung Cancer.
Int J Nanomedicine. 2020 Jun 30;15:4691-4703. doi: 10.2147/IJN.S244172. eCollection 2020.
3
Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo.
Int J Nanomedicine. 2014 Aug 21;9:4043-53. doi: 10.2147/IJN.S66164. eCollection 2014.
4
Development of GdN@C encapsulated redox nanoparticles for high-performance magnetic resonance imaging.
J Biomater Sci Polym Ed. 2017 Jul-Aug;28(10-12):1036-1050. doi: 10.1080/09205063.2017.1288774. Epub 2017 Feb 8.
5
Gd-encapsulated carbonaceous dots for accurate characterization of tumor vessel permeability in magnetic resonance imaging.
Nanomedicine. 2019 Oct;21:102074. doi: 10.1016/j.nano.2019.102074. Epub 2019 Jul 31.
6
Tumor-Targeted and Clearable Human Protein-Based MRI Nanoprobes.
Nano Lett. 2017 Jul 12;17(7):4096-4100. doi: 10.1021/acs.nanolett.7b00828. Epub 2017 Jun 26.
7
Green Synthesis of Sub-10 nm Gadolinium-Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor-Bearing Mice in Magnetic Resonance Imaging.
Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201600865. Epub 2016 Dec 22.
8
A novel gadolinium-based trimetasphere metallofullerene for application as a magnetic resonance imaging contrast agent.
Invest Radiol. 2013 Nov;48(11):745-54. doi: 10.1097/RLI.0b013e318294de5d.
9
Gadolinium-loaded chitosan nanoparticles as magnetic resonance imaging contrast agents for the diagnosis of tumor.
J Biomed Nanotechnol. 2013 May;9(5):863-9. doi: 10.1166/jbn.2013.1584.
10
Facile Synthesis of Gadolinium Chelate-Conjugated Polymer Nanoparticles for Fluorescence/Magnetic Resonance Dual-Modal Imaging.
Anal Chem. 2018 Feb 6;90(3):1992-2000. doi: 10.1021/acs.analchem.7b04078. Epub 2018 Jan 17.
引用本文的文献
1
Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers.
Adv Mater. 2024 Sep;36(36):e2402479. doi: 10.1002/adma.202402479. Epub 2024 Jul 29.
2
RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction.
Nanomedicine (Lond). 2024;19(18-20):1585-1600. doi: 10.1080/17435889.2024.2365623. Epub 2024 Jul 16.
3
Metal-doped carbon dots for biomedical applications: From design to implementation.
Heliyon. 2024 May 31;10(11):e32133. doi: 10.1016/j.heliyon.2024.e32133. eCollection 2024 Jun 15.
4
Facile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy.
J Nanobiotechnology. 2024 Mar 2;22(1):88. doi: 10.1186/s12951-024-02360-4.
5
A comparative multi-level toxicity assessment of carbon-based Gd-free dots and Gd-doped nanohybrids from coffee waste: hematology, biochemistry, histopathology and neurobiology study.
Sci Rep. 2023 Jun 8;13(1):9306. doi: 10.1038/s41598-023-36496-4.
6
Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics.
Theranostics. 2023 May 21;13(9):3064-3102. doi: 10.7150/thno.80579. eCollection 2023.
7
A smartphone-based fluorospectrophotometer and ratiometric fluorescence nanoprobe for on-site quantitation of pesticide residue.
iScience. 2023 Apr 1;26(4):106553. doi: 10.1016/j.isci.2023.106553. eCollection 2023 Apr 21.
8
Synthesis and characterization of Gd-loaded hyaluronic acid-polydopamine nanoparticles as a dual contrast agent for CT and MRI scans.
Sci Rep. 2023 Mar 18;13(1):4520. doi: 10.1038/s41598-023-31252-0.
9
Recent Developments in Heteroatom/Metal-Doped Carbon Dot-Based Image-Guided Photodynamic Therapy for Cancer.
Pharmaceutics. 2022 Sep 5;14(9):1869. doi: 10.3390/pharmaceutics14091869.
10
Targeted nanotherapy for kidney diseases: a comprehensive review.
Nephrol Dial Transplant. 2023 May 31;38(6):1385-1396. doi: 10.1093/ndt/gfac233.
本文引用的文献
1
Facile preparation of gadolinium(iii) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imaging.
J Mater Chem B. 2014 Sep 14;2(34):5541-5549. doi: 10.1039/c4tb00709c. Epub 2014 Jul 23.
2
In vitro Gd-DTPA relaxometry studies in oxygenated venous human blood and aqueous solution at 3 and 7 T.
Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):169-76. doi: 10.1002/cmmi.1568.
3
Label-free luminescent mesoporous silica nanoparticles for imaging and drug delivery.
Theranostics. 2013 Aug 10;3(9):650-7. doi: 10.7150/thno.6668. eCollection 2013.
4
Functional surface engineering of C-dots for fluorescent biosensing and in vivo bioimaging.
Acc Chem Res. 2014 Jan 21;47(1):20-30. doi: 10.1021/ar400023s. Epub 2013 Aug 2.
5
Simple and green synthesis of nitrogen-doped photoluminescent carbonaceous nanospheres for bioimaging.
Angew Chem Int Ed Engl. 2013 Jul 29;52(31):8151-5. doi: 10.1002/anie.201303927. Epub 2013 Jun 20.
6
Biodegradable polysilsesquioxane nanoparticles as efficient contrast agents for magnetic resonance imaging.
Small. 2013 Oct 25;9(20):3523-31. doi: 10.1002/smll.201300198. Epub 2013 Apr 24.
7
Carbon nanoparticle-based fluorescent bioimaging probes.
Sci Rep. 2013;3:1473. doi: 10.1038/srep01473.
8
Gd-based macromolecules and nanoparticles as magnetic resonance contrast agents for molecular imaging.
Curr Top Med Chem. 2013;13(4):411-21. doi: 10.2174/1568026611313040002.
9
A synergistically enhanced T(1) -T(2) dual-modal contrast agent.
Adv Mater. 2012 Dec 4;24(46):6223-8. doi: 10.1002/adma.201203169. Epub 2012 Sep 13.
10
Amphiphilic egg-derived carbon dots: rapid plasma fabrication, pyrolysis process, and multicolor printing patterns.
Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9297-301. doi: 10.1002/anie.201204381. Epub 2012 Aug 21.
Zotero 插件