Konrad Daniel, Wueest Stephan
Department of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland; Children's Research Center, University Children's Hospital, Zurich, Switzerland; and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Department of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland; Children's Research Center, University Children's Hospital, Zurich, Switzerland; and.
Physiology (Bethesda). 2014 Sep;29(5):304-13. doi: 10.1152/physiol.00014.2014.
Obesity is associated with altered gut microbiota composition and impaired gut barrier function. These changes, together with interrelated mesenteric adipose tissue inflammation, result in increased release of pro-inflammatory cytokines, bacteria-derived factors, and lipids into the portal circulation, promoting the development of (hepatic) insulin resistance. Herein, the potential impact of obesity-related changes in gut and visceral adipose tissue biology on the development of insulin resistance and Type 2 diabetes is reviewed.
肥胖与肠道微生物群组成改变和肠道屏障功能受损有关。这些变化，连同相关的肠系膜脂肪组织炎症，导致促炎细胞因子、细菌衍生因子和脂质向门静脉循环的释放增加，促进（肝脏）胰岛素抵抗的发展。本文综述了肥胖相关的肠道和内脏脂肪组织生物学变化对胰岛素抵抗和2型糖尿病发展的潜在影响。
