Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
Dig Endosc. 2015 Jan;27(2):182-8. doi: 10.1111/den.12354. Epub 2014 Oct 28.
We have developed a technique for endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to an esophageal ulcer following endoscopic submucosal dissection (ESD). The epithelial cell sheets successfully prevented esophageal stricture after ESD. Key technology is that epithelial cell sheets cultured from oral mucosal tissue and attached proteins can be harvested using cell sheet technology and can be transplanted to a wound site without the use of adhesive material. This regenerative procedure can promote the epithelialization of ulceration safely and effectively. In the near future, the development of advanced endoscopic treatment of regenerative medicine shows promise.
我们开发了一种内镜下移植培养的自体口腔黏膜上皮细胞片治疗内镜黏膜下剥离术（ESD）后食管溃疡的技术。上皮细胞片成功预防了 ESD 后的食管狭窄。关键技术是可以使用细胞片技术从口腔黏膜组织中采集培养的上皮细胞片和附着蛋白，并将其移植到创面，而无需使用黏附材料。这种再生程序可以安全有效地促进溃疡的上皮化。在不久的将来，再生医学的先进内镜治疗的发展前景广阔。
